Evaluation of the antiedematogenic activity of artemetin isolated from Cordia curassavica DC

dc.creatorBayeux, M.C.
dc.creatorFernandes, A.T.
dc.creatorFoglio, M.A.
dc.creatorCarvalho, J.E.
dc.date2002-10-01
dc.date2014-07-17T15:05:02Z
dc.date2015-11-26T11:25:28Z
dc.date2014-07-17T15:05:02Z
dc.date2015-11-26T11:25:28Z
dc.date.accessioned2018-03-28T20:39:26Z
dc.date.available2018-03-28T20:39:26Z
dc.identifierBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 10, p. 1229-1232, 2002.
dc.identifier0100-879X
dc.identifierS0100-879X2002001000017
dc.identifier10.1590/S0100-879X2002001000017
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2002001000017
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000017
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/24200
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/24200
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1233352
dc.descriptionThe species Cordia curassavica (Boraginaceae), known popularly as erva baleeira, is used in folk medicine for the treatment of several inflammatory processes and as a healing agent. The objective of the present study was to evaluate the antiedematogenic activity of crude dichloromethane extracts of Cordia curassavica and of the artemetin-enriched fraction. The crude extract and artemetin fraction were tested in the model of carrageenin-induced paw edema in male Swiss mice (25-30 g). The crude dichloromethane extract (300 and 1000 mg/kg, po, N = 6) showed significant antiedematogenic activity, reducing the edema by 42, 57 and 45% and 46, 62 and 69%, 3, 4 and 5 h after carrageenin administration, respectively. Indomethacin (10 mg/kg, po, N = 6) reduced the edema by 45 and 48%, after 4 and 5 h, but the artemetin-enriched fraction (30, 100 and 300 mg/kg, po, N = 6) had no activity. The dichloromethane extract (300 and 1000 mg/kg, po, N = 6) also showed antinociceptive activity by reducing acetic acid-induced writhing in mice from 37.1 ± 2.28 (control) to 17.3 ± 1.34 and 13.2 ± 1.44, respectively, but had no activity in the hot-plate test.
dc.description1229
dc.description1232
dc.languageen
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsaberto
dc.sourceSciELO
dc.subjectCordia curassavica
dc.subjectCordia verbenaceae
dc.subjectAntiedematogenic
dc.subjectAnti-inflammatory
dc.subjectMedicinal plants
dc.titleEvaluation of the antiedematogenic activity of artemetin isolated from Cordia curassavica DC
dc.typeArtículos de revistas


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