Artículos de revistas
Alternative mitochondrial functions in cell physiopathology: beyond ATP production
Registro en:
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 33, n. 2, p. 241-250, 2000.
0100-879X
S0100-879X2000000200014
10.1590/S0100-879X2000000200014
Autor
Kowaltowski, A.J.
Institución
Resumen
It is well known that mitochondria are the main site for ATP generation within most tissues. However, mitochondria also participate in a surprising number of alternative activities, including intracellular Ca2+ regulation, thermogenesis and the control of apoptosis. In addition, mitochondria are the main cellular generators of reactive oxygen species, and may trigger necrotic cell death under conditions of oxidative stress. This review concentrates on these alternative mitochondrial functions, and their role in cell physiopathology. 241 250