Patentes
Use Of Phthalimide And/or Sulphonamide Derivatives In The Treatment Of Diseases Which Require Reducing The Tnf-alpha Levels And An Exogenous Source Of Nitric Oxide, Phthalimide Derivatives, Sulphonamide Derivatives, And A Method For Obtaining A Sulphonamide Derivative
Autor
Dos Santos Jean Leandro [br]
Chung Man Chin [br]
Moreira Lima Lidia [br]
Ferreira Costa Fernando [br]
Lanaro Carolina [br]
Institución
Resumen
Preparation and use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, having activities in increasing gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-a leveis and an exogenous source of nitric oxide, such as sickle-cell disease. The functionalized phthalimide derivatives are designed from the prototypes thalidomide and hydroxyurea. US2012245364 (A1); US8338474 (B2) C07D209/48
US201213404777 C07D209/48