Tuberculosis assumes several clinical forms and can affect almost any part of the human body. Before pharmacological treatment was discovered, half of afflicted subjects died before two years. Tuberculosis can be considered an ancient disease and worldwide strategy to eradicate it has only met with partial success. Presently in Mexico there has been an increase in number of conventional and extra-pulmonary tuberculosis cases. Non pulmonary sites can be found in the gastro-intestinal tract, central nervous system, skin, lymphs, mouth, temporomandibular articulation as well as ganglia at the cervical region. Diagnosis of extra-pulmonary tuberculosis is complicated, this is due to the variety of presentations and multiple differential diagnoses that need to be discarded. There are different diagnostic tests, some of them might even give a false negative. Standard diagnosis is achieved through mycobacterial culture. A systematic analysis of the literature is presented in this study; four clinical cases with tuberculosis cervical-facial manifestations are studied, describing protocol used to corroborate diagnosis and discard other conditions.