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Determination of sparfloxacin and its degradation products by HPLC-PDA
(Oxford University Press, 2014)
Molecular hybridization: A useful tool in the design of new drug prototypes
(2007-07-01)
Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hyrid compound with improved affinity and ...
Molecular hybridization: A useful tool in the design of new drug prototypes
(2007-07-01)
Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hyrid compound with improved affinity and ...
Three new platinum complexes containing fluoroquinolones and DMSO: Cytotoxicity and evaluation against drug-resistant tuberculosis
(Elsevier B.V., 2018-06-01)
This work describes the synthesis, characterization and biological evaluation of three platinum complexes of the type [Pt(DMSO)(L)Cl]Cl, in which L represents a fluoroquinolone, namely, ciprofloxacin (cpl), ofloxacin (ofl), ...
Complexos metálicos de fluorquinolonas: síntese, atividade biológica e estudos do mecanismo de ação
(Universidade Federal de Minas GeraisUFMG, 2013-07-26)
In this work, three Au(III) complexes of the fluoroquinolones norfloxacin (NOR), levofloxacin (LEVO) and sparfloxacin (SPAR) were prepared and characterized with physicochemical and spectroscopic techniques: [AuCl2(NOR)]Cl.2H2O ...
Complexos de Cu(II) de algumas fluorquinolonas: sínteses, atividade anti-T.cruzi e investigação do mecanismo de ação
(Universidade Federal de Minas GeraisUFMG, 2011-07-18)
Chagas disease, caused by the Trypanosoma cruzi protozoa, is an endemic parasitosis which affects about 12 million people in Latin America. The only two available drugs for the treatment of Chagas disease are Nifurtimox ...
Estudos eletroquímicos de complexos de Cu(II) de antibióticos da classe das fluorquinolonas
(Universidade Federal de Minas GeraisUFMG, 2011-02-28)
The fluoroquinolones represent an important class of synthetic compounds that have been studied because of its chelating capacity and their applications as antibacterial agents. Recent studies for the blood trypomastigotes ...