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Genotoxic evaluation of the antimalarial drugs artemisinin and artesunate in human HepG2 cells and effects on CASP3 and SOD1 gene expressions
(2013-07-24)
The malaria treatment recommended by the World Health Organization involves medicines derived from artemisinin, an active compound extracted from the plant Artemisia annua, and some of its derivatives, such as artesunate. ...
Genotoxic evaluation of the antimalarial drugs artemisinin and artesunate in human HepG2 cells and effects on CASP3 and SOD1 gene expressions
(2013-07-24)
The malaria treatment recommended by the World Health Organization involves medicines derived from artemisinin, an active compound extracted from the plant Artemisia annua, and some of its derivatives, such as artesunate. ...
Identification of Novel Compounds Inhibiting Chikungunya Virus-Induced Cell Death by High Throughput Screening of a Kinase Inhibitor Library
(Public Library Science, 2013-10-01)
Chikungunya virus (CHIKV) is a mosquito-borne arthrogenic alphavirus that causes acute febrile illness in humans accompanied by joint pains and in many cases, persistent arthralgia lasting weeks to years. The re-emergence ...
Cuantificación de la actividad antibacteriana de aceites esenciales frente a Escherichia coli ATCCC 25922 y Escherichia coli portadora de betalactamasas de espectro extendido
(Universidad de Cuenca, 2023-01-11)
Antibiotic resistance due to the production of the extended-spectrum β-lactamases (ESBL)
by Escherichia coli has become a threat to public health. For this reason, the use of
essential oils (EOs) is considered a new ...
Reactions of excited states of phenoxazin-3-one dyes with amino acids
(Wiley Blackwell Publishing, Inc, 2005-07)
The interaction with amino acids of the excited states of the N-oxide resazurin and its deoxygenation product resorufin, has been studied in aqueous solution at pH 7.5. Steady-state and time-resolved studies show that the ...
Photoreaction and photopolymerization studies on phenoxazin dyes/diphenyliodonium chloride salt
(Elsevier Science Sa, 2007-04)
The photophysics and photochemistry of the dyes resazurin (Rz) and resorufin (Rf) in absence and presence of diphenyliodonium chloride (DPIC) were investigated in water at pH 10. The dye/DPIC combination undergoes photoreaction ...
Isoniazid and verapamil modulatory activity and efflux pump gene expression in Mycobacterium tuberculosis
(Int Union Against Tuberculosis Lung Disease (i U A T L D), 2020-06-01)
INTRODUCTION: Resistance to first-line anti-tuberculosis drugs is a major concern in the treatment of the disease. New strategies, such as the use of efflux pump inhibitors (EPIs), are being investigated to improve the ...
Morphological changes and differentially expressed efflux pump genes in Mycobacterium tuberculosis exposed to a rifampicin and verapamil combination
(Churchill Livingstone, 2016-03-01)
The aim of the present study was to (i) evaluate the in vitro action of rifampicin (RIF), ethambutol or isoniazid with efflux pumps inhibitors (EPIs) in Mycobacterium tuberculosis (Mtb) H(37)Rv and (ii) evaluate the ...
Potential of Casiopeínas® Copper Complexes and Antituberculosis Drug Combination against Mycobacterium tuberculosis
(2016-02-25)
New compounds with antituberculosis activity and their combination with classic drugs have been evaluated to determine possible interactions and antagonism. The aim of this study was to evaluate the in vitro activity of ...