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Molecular mechanisms in liver ischemic-reperfusion injury and ischemic preconditioning Mecanismos moleculares en el daño por isquemia-reperfusión hepática y en el preacondicionamiento isquémico
(2005)
Ischemia-reperfusion (IR) liver injury is associated with temporary clamping of hepatoduodenal ligament during liver surgery, hypoperfusion shock and graft failure after liver transplantation. Mechanisms of IR liver injury ...
Cellular mechanisms against ischemia reperfusion injury induced by the use of anesthetic pharmacological agents
(Elsevier, 2014)
Ischemia–reperfusion (IR) cycle in the myocardium is associated with activation of an injurious cascade,
thus leading to new myocardial challenges, which account for up to 50% of infarct size. Some evidence
implicates ...
Potentiation of ischemia-reperfusion liver injury by hyperthyroidism in the rat
(1997)
Parameters related to hepatic oxidative stress, cell injury, and liver histology were determined in control rats and in animals treated with 3,3',5- triiodothyronine (T3), after in vitro perfusion under normoxic or ischemia- ...
Calpain translocation and activation as pharmacological targets during myocardial ischemia/reperfusion
(2010)
Calpains contribute to reperfusion-induced myocardial cell death. However, it remains controversial whether its activation occurs during ischemia or reperfusion. We investigated the regulation and time-course of calpain ...
TRPM4 activation by chemically- and oxygen deprivation-induced ischemia and reperfusion triggers neuronal death
(Taylor & Francis, 2017)
Cerebral ischemia-reperfusion injury triggers a deleterious process ending in neuronal death. This process has two components, a glutamate-dependent and a glutamate-independent mechanism. In the glutamate-independent ...
Prevention of liver ischemia reperfusion injury by a combined thyroid hormone and fish oil protocol
(2012)
Several preconditioning strategies are used to prevent ischemia-reperfusion (IR) liver injury, a deleterious condition associated with tissue resection, transplantation or trauma. Although thyroid hormone (T3) administration ...
Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase and at reperfusion
(Wiley, 2018)
The Reperfusion Injury Salvage Kinase (RISK) pathway is considered the main pro-survival kinase cascade mediating the ischaemic preconditioning (IPC) cardioprotective effect. To assess the role of PI3K-Akt, its negative ...
Histone deacetylase inhibition blunts ischemia/reperfusion Injury by inducing cardiomyocyte autophagy
(American Hearth Association, 2014)
Background—Reperfusion accounts for a substantial fraction of the myocardial injury occurring with ischemic heart disease.
Yet, no standard therapies are available targeting reperfusion injury. Here, we tested the hypothesis ...
Liver preconditioning induced by iron in a rat model of ischemia/reperfusion
(Elsevier, 2011)
Aims: Liver preconditioning against ischemia–reperfusion (IR) injury is a major area of experimental research,
in which regulation of gene expression with cytoprotective responses due to transient oxidative stress
development ...
Protection against in vivo liver ischemia-reperfusion injury by n-3 long-chain polyunsaturated fatty acids in the rat
(2010)
N-3 polyunsaturated fatty acids (n-3 PUFA) affect inflammatory processes. This study evaluated the effects of dietary supplementation with fish oil on hepatic ischemia-reperfusion (IR) injury in the rat. Parameters of liver ...