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(+)alpha-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo
(NATURE PUBLISHING GROUPLONDON, 2012)
The vitamin E derivative (+)alpha-tocopheryl succinate (alpha-TOS) exerts pro-apoptotic effects in a wide range of tumors and is well tolerated by normal tissues. Previous studies point to a mitochondrial involvement in ...
Aberrant Expression of the MLL5, BAALC, ID1, and WT1 Genes Is Associated with Higher Induction Mortality and Poorer Overall Survival in Acute Promyelocytic Leukemia Patients Treated with ATRA and Anthracycline-Based Chemotherapy: An International Consortium On Acute Promyelocytic Leukemia Study
(Amer Soc HematologyWashington, 2012)
Acute promyelocytic leukemia with t(15;17): frequency of additional clonal chromosome abnormalities and FLT3 mutations
(Taylor & Francis Ltd, 2008-01-01)
Cellular Promyelocytic Leukemia Protein Is an Important Dengue Virus Restriction Factor
(Public Library Of Science, 2015-05)
The intrinsic antiviral defense is based on cellular restriction factors that are constitutively expressed and, thus, active even before a pathogen enters the cell. The promyelocytic leukemia (PML) nuclear bodies (NBs) are ...
Acute promyelocytic leukemia: the study of t(15;17) translocation by fluorescent in situ hybridization, reverse transcriptase-polymerase chain reaction and cytogenetic techniques
(Associação Brasileira de Divulgação Científica, 2001-06-01)
Acute promyelocytic leukemia (AML M3) is a well-defined subtype of leukemia with specific and peculiar characteristics. Immediate identification of t(15;17) or the PML/RARA gene rearrangement is fundamental for treatment. ...
An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein
(Academic Press Inc Elsevier Science, 2010)
Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia
(AMER SOC HEMATOLOGY, 2009)
Acute promyelocytic leukemia (APL) is characterized by a block in differentiation and accumulation of promyelocytes in the bone marrow and blood. The majority of APL patients harbor the t(15: 17) translocation leading to ...
Apoptosis induction by (+)alpha-tocopheryl succinate in the absence or presence of all-trans retinoic acid and arsenic trioxide in NB4, NB4-R2 and primary APL cells
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
We analyzed the effect of (+)alpha-tocopheryl succinate (alpha-TOS) alone or associated with arsenic trioxide (ATO) or all-trans retinoid acid (ATRA) in acute promyelocytic leukemia (APL). alpha-TOS-induced apoptosis in ...
Leucemia promielocítica aguda: do histórico ao tratamentoAcute promyelocytic leukemia: from history to treatment
(Universidade Federal do Rio Grande do NorteBrasilUFRNBiomedicinaCentro de Biociências, 2022)