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Macrophage immunophenotype but not anti-inflammatory profile is modulated by peroxisome proliferator-activated receptor gamma (PPAR gamma) in exercised obese mice
(W W F Verlagsgesellschaft Gmbh, 2020-01-01)
Moderate aerobic training may be therapeutic for chronic low-grade inflammatory diseases due to the associated antiinflammatory response that is mediated by immune cells. The peroxisome proliferator-activated receptor gamma ...
Macrophage immunophenotype but not anti-inflammatory profile is modulated by peroxisome proliferator-activated receptor gamma (PPARγ) in exercised obese mice
(2020-01-01)
Moderate aerobic training may be therapeutic for chronic low-grade inflammatory diseases due to the associated anti-inflammatory response that is mediated by immune cells. The peroxisome proliferator-activated receptor ...
IL-6 promotes M2 macrophage polarization by modulating purinergic signaling and regulates the lethal release of nitric oxide during Trypanosoma cruzi infection
(Elsevier Science, 2017-01)
The production of nitric oxide (NO) is a key defense mechanism against intracellular pathogens but it must be tightly controlled in order to avoid excessive detrimental oxidative stress. In this study we described a novel ...
IL-6 promotes M2 macrophage polarization by modulating purinergic signaling and regulates the lethal release of nitric oxide during Trypanosoma cruzi infection.
(Elsevier Science, 2017-04)
The production of nitric oxide (NO) is a key defense mechanism against intracellular pathogens but it must be tightly controlled in order to avoid excessive detrimental oxidative stress. In this study we described a novel ...
Second generation BTK inhibitors impair the anti-fungal response of macrophages and neutrophils
(Wiley-liss, div John Wiley & Sons Inc., 2020-04)
BTK inhibitors (BTKi) play a major role in the treatment of Chronic Lymphocytic Leukemia (CLL). Ibrutinib, the first in class BTKi, impairs macrophage and neutrophil functions and also cell-mediated effector mechanisms of ...
Pro-inflammatory monocyte profile in patients with major depressive disorder and suicide behaviour and how ketamine induces antiinflammatory M2 macrophages by NMDAR and mTOR
(The Lancet, 2019-12)
Background: Depression is a highly prevalent disorder that is one of the leading causes of disability worldwide. Despite an unknown aetiology, evidence suggests that the innate and adaptive immune systems play a significant ...
Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing
(2020-08-01)
AIMS: This study aimed to investigate the effect of lymphocytes in wound healing and the underlying mechanisms, in diabetic and non-diabetic mice, using Balb/c recombination activating gene (Rag)-2 and interleukin 2 receptor ...
Potencial imunomodulador de substâncias bioativas vegetais na ativação do inflamassoma no contexto da paracoccidioidomicose
(Universidade Estadual Paulista (Unesp), 2021-02-01)
A paracoccidioidomicose (PCM) é micose sistêmica causada por fungos do gênero Paracoccidioides. É uma doença endêmica na América Latina e que se apresenta predominantemente em indivíduos do sexo masculino (90%) com idade ...
Macrófagos regulatórios controlam a inflamação e promovem a recuperação em modelo experimental de doença inflamatória intestinal
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE PATOLOGIAPrograma de Pós-Graduação em PatologiaUFMG, 2020-04-30)
Inflammatory bowel disease is a group of digestive system diseases of complex pathogenesis, multifactorial and symptomatic treatment, and there is still no effective curative treatment. The imbalance of the local immune ...