Buscar
Mostrando ítems 11-20 de 289
Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation And Hypertension Are Critically Dependent On Peroxynitrite Formation
(2016)
Oxidative stress is involved in the development of carotid body (CB) chemosensory potentiation and systemic hypertension induced by chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea. We tested ...
Radical acetylation of 2`-deoxyguanosine and L-histidine coupled to the reaction of diacetyl with peroxynitrite in aerated medium
(AMER CHEMICAL SOC, 2008)
Diacetyl, like other alpha-dicarbonyl compounds, is reportedly cytotoxic and genotoxic. A food and cigarette contaminant, it is related with alcohol hepatotoxicity and lung disease. Peroxynitrite is a potent oxidant formed ...
Role of peroxynitrite in macrophage microbicidal mechanisms in vivo revealed by protein nitration and hydroxylation
(Pergamon-elsevier Science LtdOxfordInglaterra, 2001)
Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of Trypanosoma Cruzi iron-superoxide dismutases (fe-sods) A and B. Disparate susceptibilities due to the repair of tyr35 radical by cys83 in fe-sodb through intramolecular electron transfer
(American Society for Biochemistry and Molecular Biology, 2014-05)
Trypanosoma cruzi, the causative agent of Chagas disease, contains exclusively iron-dependent superoxide dismutases (Fe-SODs) located in different subcellular compartments. Peroxynitrite, a key cytotoxic and oxidizing ...
Formation of nitrosyl hemoglobin and nitrotyrosine during murine leishmaniasis
(Amer Soc PhotobiologyAugusta, 1996)
Reactivity of 1,4-dihydropyridines toward SIN-1-derived peroxynitrite
(KLUWER ACADEMIC/PLENUM PUBL, 2004-10)
Purpose. To study the reactivity of C4-substituted 1,4-dihydropyridines (1,4-DHP), with either secondary or tertiary nitrogen in the dihydropyridine ring, toward SIN-1-derived peroxynitrite in aqueous media at pH 7.4.
Methods. ...
Kinetics of nitrite reduction and peroxynitrite formation by ferrous heme in human cystathionine β-synthase
(The American Society for Biochemistry and Molecular Biology, 2016)
Cystathionine β-synthase (CBS) is a pyridoxal phosphate-dependent enzyme that catalyzes the condensation of homocysteine with serine or with cysteine to form cystathionine and either water or hydrogen sulfide, respectively. ...
Chronically administered acetaminophen and the ischemia/reperfused myocardium
(Soc Experimental Biology MedicineMaywoodEUA, 2003)
Cyclic GMP-independent mechanisms contribute to the inhibition of platelet adhesion by nitric oxide donor: A role for alpha-actinin nitration
(Natl Acad SciencesWashingtonEUA, 2006)
Radical acylation of L-lysine derivatives and L-lysine-containing peptides by peroxynitrite-treated diacetyl and methylglyoxal
(Informa Healthcare, 2014-03-01)
Highly electrophilic alpha-dicarbonyls such as diacetyl, methylglyoxal, 3-deoxyglucosone, and 4,5- dioxovaleric acid have been characterized as secondary catabolites that can aggregate proteins and form DNA nucleobase ...