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Cardiac dysfunction, mitochondrial architecture, energy production, and inflammatory pathways: Interrelated aspects in endotoxemia and sepsis
(Pergamon-Elsevier Science Ltd, 2016-12)
Septic patients with myocardial dysfunction have a 3-fold increase in mortality compared with patients without cardiovascular impairment, and usually show myocarditis, disruption of the contractile apparatus, increased ...
Progesterone and Allopregnanolone Neuroprotective Effects in the Wobbler Mouse Model of Amyotrophic Lateral Sclerosis
(Springer/Plenum Publishers, 2021-06)
Progesterone regulates a number of processes in neurons and glial cells not directly involved in reproduction or sex behavior. Several neuroprotective effects are better observed under pathological conditions, as shown in ...
Diseño y Evaluación Teórica y Experimental in vitro de Compuestos Derivados de Apocinina como Posibles Inhibidores de NADPH oxidasa
(2011-06-28)
The oxidative stress produced by high concentrations of superoxide anion O2•- derived from NADPH oxidase 2 (Nox2) in the vascular endothelium has been linked to cardiovascular diseases such as hypertension and atherosclerosis ...
Platelet-derived exosomes from septic shock patients induce myocardial dysfunction
(2007)
Abstract
Introduction
Mechanisms underlying inotropic failure in septic shock are incompletely understood. We previously ...
Platelet-derived exosomes from septic shock patients induce myocardial dysfunction
(Biomed Central Ltd, 2007-01-01)
Introduction Mechanisms underlying inotropic failure in septic shock are incompletely understood. We previously identified the presence of exosomes in the plasma of septic shock patients. These exosomes are released mainly ...
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K
(Elsevier B.V., 2018)
© 2018 Elsevier Inc. The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) induces complex neuronal signaling cascades that are critical for the cellular changes underlying synaptic plasticity. These pathways include ...
Pathophysiology of mesenteric ischemia/reperfusion: a review.
(2005-07-01)
During ischemia, the cell structures are progressively damaged, but restoration of the blood flow, paradoxically, intensifies the lesions caused by the ischemia. The mechanisms of ischemia injury and reperfusion (I/R) have ...
Pathophysiology of mesenteric ischemia/reperfusion: a review.
(2005-07-01)
During ischemia, the cell structures are progressively damaged, but restoration of the blood flow, paradoxically, intensifies the lesions caused by the ischemia. The mechanisms of ischemia injury and reperfusion (I/R) have ...