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Hormesis: Protecting neurons against cellular stress in Parkinson disease
(Taylor and Francis Inc., 2012)
Protein folding stress is a salient feature of the most frequent neurodegenerative diseases. Although the accumulation of abnormally folded proteins is a well-characterized event underlying the pathology, the way cells ...
Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson‘s disease
(Oxford University Press, 2008-12)
Parkinson's disease is a neurodegenerative disorder with uncertain aetiology and ill-defined pathophysiology. Activated microglial cells in the substantia nigra (SN) are found in all animal models of Parkinson's disease ...
Mitochondrial energy metabolism in neurodegeneration associated with methylmalonic acidemia
(SPRINGER/PLENUM PUBLISHERS, 2011)
Methylmalonic acidemia is one of the most prevalent inherited metabolic disorders involving neurological deficits. In vitro experiments, animal model studies and tissue analyses from human patients suggest extensive ...
Mitochondria and calcium regulation as basis of neurodegeneration associated with aging
(Frontiers Media S.A., 2018)
© 2018 Müller, Ahumada-Castro, Sanhueza, Gonzalez-Billault, Court and Cárdenas.Age is the main risk factor for the onset of neurodegenerative diseases. A decline of mitochondrial function has been observed in several ...
Iron toxicity in neurodegeneration
(2012)
Iron is an essential element for life on earth, participating in a plethora of cellular processes where one-electron transfer reactions are required. Its essentiality, coupled to its scarcity in aqueous oxidative environments, ...
Contribution of Tau pathology to mitochondrial impairment in neurodegeneration
(Frontiers Media S.A., 2018)
Early and late neurodegeneration and memory disruption after intracerebroventricular streptozotocin
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012-10)
Glucose metabolism and insulin signaling disruptions in the brain have been proposed as a likely etiology of Alzheimer's disease. The aim of the present study was to investigate the time course of cognitive impairments ...
Exploring signatures of neurodegeneration in early-onset older-age bipolar disorder and behavioral variant frontotemporal dementia
Introduction: Older-age bipolar disorder (OABD) may involve neurocognitive decline and behavioral disturbances that could share features with the behavioral variant of frontotemporal dementia (bvFTD), making the differential ...
Iron and glutathione at the crossroad of redox metabolism in neurons
(Sociedad de Biología de Chile, 2006)