Now showing items 11-20 of 3598
Effects of Bidens pilosa L. on the molecular targets in the TNBS-model of intestinal inflammation
(Georg Thieme Verlag Kg, 2014-11-01)
Translation controlled mRNAs: New drug targets in infectious diseases?
(Bentham Science Publishers B.V., 2009)
Recent data from a series of laboratories has pinpointed the relevant role of translation control on the regulation of gene expression. In particular, an analysis of T cell activation has led to demonstrate that during ...
Synergizing immunotherapy with molecularly targeted anticancer treatment
The therapeutic opportunity for anticancer kinase inhibitors (KIs) that block cell-signaling pathways is materializing. Yet, these molecular-targeted therapies are not tailored to be allies of the immune system, and often ...
Identification of potential therapeutic targets in prostate cancer through a cross-species approach
Genetically engineered mouse models of cancer can be used to filter genome-wide expression datasets generated from human tumours and to identify gene expression alterations that are functionally important to cancer development ...
Conservation of dual-targeted proteins in Arabidopsis and rice points to a similar pattern of gene-family evolution
(SPRINGER HEIDELBERG, 2009)
Gene duplication followed by acquisition of specific targeting information and dual targeting were evolutionary strategies enabling organelles to cope with overlapping functions. We examined the evolutionary trend of ...
Evolutionary History of Arabidopsis thaliana Aminoacyl-tRNA Synthetase Dual-Targeted Proteins
(OXFORD UNIV PRESS, 2011)
Aminoacyl-transfer RNA (tRNA) synthetases (aaRS) are key players in translation and act early in protein synthesis by mediating the attachment of amino acids to their cognate tRNA molecules. In plants, protein synthesis ...
Chemistry and Biological Activity of Coumarins at Molecular Level
(Natural Products, 2014-08)
Synthetic coumarins were prepared using ionic liquids as an environmental friendly alternative with high yields. The compounds 3,4-dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) have ...
Hypertension and exercise: A search for mechanisms