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Dietary fish oil ameliorates adipose tissue dysfunction in insulin-resistant rats fed a sucrose-rich diet improving oxidative stress, peroxisome proliferator-activated receptor γ and uncoupling protein 2
(Royal Society of Chemistry, 2018-04)
This work aimed to assess the possible beneficial effects of dietary fish oil (FO) on the preexisting adipose tissue dysfunction through the improvement or reversion of the mechanisms underlying oxidative stress and ...
Activated alpha-2 macroglobulin improves insulin response via lrp1 in lipid-loaded hl-1 cardiomyocytes
(Multidisciplinary Digital Publishing Institute, 2021-06-28)
Activated alpha-2 Macroglobulin (α2M*) is specifically recognized by the cluster I/II of LRP1 (Low-density lipoprotein Receptor-related Protein-1). LRP1 is a scaffold protein for insulin receptor involved in the insulin-induced ...
Functional autoreactive anti-β2 adrenergic antibodies may contribute to insulin resistance profile in patients with chronic chagas disease
(Multidisciplinary Digital Publishing Institute, 2021-03)
Potential activation of β2 adrenergic receptors (β2AR) by specific autoreactive antibodies (Abs) that arise during the host reaction to Trypanosoma cruzi, could contribute to the elevated prevalence of metabolic disturbances ...
Alteration in the expression of inflammatory parameters as a result of oxidative stress produced by moderate zinc deficiency in rat lung
(Taylor & Francis, 2010-02)
Suboptimal intake of dietary zinc (Zn) is one of the most common nutritional problems worldwide. Previously, the authors have shown that zinc deficiency (ZD) produces oxidative and nitrosative stress in lung of male rats. ...
Dopaminergic drugs in type 2 diabetes and glucose homeostasis
(Elsevier, 2016-07)
The importance of dopamine in central nervous system function is well known, but its effects on glucose homeostasis and pancreatic β cell function are beginning to be unraveled. Mutant mice lacking dopamine type 2 receptors ...
Saturated fat-rich diet increases fetal lipids and modulates LPL and leptin receptor expression in rat placentas
(BioScientifica, 2013-04)
Metabolic alterations in obese and overweight mothers impact the placenta and the fetus, leading to anomalies in fetal growth and lipid accretion. The primary aim of the study was to examine the effect of a saturated ...
LRP1-Mediated AggLDL endocytosis promotes pholesteryl ester accumulation and impairs insulin response in HL-1 cells
(MDPI, 2020-01)
The cardiovascular disease (CVD) frequently developed during metabolic syndrome and type-2 diabetes mellitus is associated with increased levels of aggregation-prone small LDL particles. Aggregated LDL (aggLDL) internalization ...
Chronic hyperprolactinemia evoked by disruption of lactotrope dopamine D2 receptors impacts on liver and adipocyte genes related to glucose and insulin balance
(American Physiological Society, 2016-12)
We studied the impact of high prolactin titers on liver and adipocyte gene expression related to glucose and insulin homeostasis in correlation with obesity onset. To that end we used mutant female mice that selectively ...
Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism
(Elsevier, 2020-03)
This study investigates the possible mechanisms involved in the beneficial effect of chia seed on skeletal muscle lipotoxicity and insulin resistance in rats fed a sucrose-rich diet (SRD). Results showed that chia seed ...
High molecular weight chitosan based particles for insulin encapsulation obtained via nanospray technology
(Taylor & Francis, 2020-08)
The objective of this work was to obtain Chitosan (CS) based particles for Insulin (INS) encapsulation, via nanospray drying of a feeding solution containing equal amounts of both components (0.1% w/v total solids content). ...