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Chronic administration of the angiotensin type 2 receptor agonist C21 improves insulin sensitivity in C57BL/6 mice
(Wiley, 2018-08)
The renin–angiotensin system modulates insulin action. Angiotensin type 1 receptor exerts a deleterious effect, whereas the angiotensin type 2 receptor (AT2R) appears to have beneficial effects providing protection against ...
Insulin-like growth factor-1 receptor regulation in activated human T lymphocytes
(Karger, 2003-12)
Objective: To investigate the kinetics of insulin-like growth factor-1 receptor (IGF-1R) expression in PHA-stimulated T lymphocytes. Methods: IGF-1R protein and mRNA were detected by flow cytometry and RT-PCR respectively, ...
Abundance of insulin-like growth factors 1 and 2, and type 1 insulin-like growth factor receptor in placentas of dogs
(Elsevier Science, 2020-10)
Insulin-like growth factors (IGFs) are among the primary compounds regulating placental development. In bitches, relative abundance of IGF1, IGF2 and IGFR1 mRNA transcripts have been studied in the pre-implantation uterus ...
Role of genetic variation in insulin-like growth factor 1 receptor on insulin resistance and arterial hypertension
(Lippincott Williams, 2010-02)
OBJECTIVE: To perform a two-stage study to explore the role of gene variants in the risk of insulin resistance and arterial hypertension. METHODS AND RESULTS: The selection of variants was performed by a first stage of ...
Alterations in the insulin signaling pathway in bovine ovaries with experimentally induced follicular persistence
(Elsevier Science Inc., 2020-12)
Reproductive diseases in dairy cows as cystic ovarian disease (COD) represent a major problem that impacts on dairy production. COD is characterized by anovulation, persistence of the dominant follicle, and interruption ...
Signaling cascade of insulin-induced stimulation of L-dopa uptake in renal proximal tubule cells
(American Physiological Society, 2008-12)
The inward L-dihydroxyphenylalanine (L-dopa) transport supplies renal proximal tubule cells (PTCs) with the precursor for dopamine synthesis. We have previously described insulin-induced stimulation of L-dopa uptake into ...
(-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice
(Elsevier Science Inc, 2016-06)
Obesity constitutes a major public health concern, being frequently associated with type 2 diabetes (T2D). Evidence from studies in humans and experimental animals suggest that consumption of the flavan-3-ol (-)-epicatechin ...
Activation of angiotensin type 2 receptors prevents diabetic complications in female db/db mice by nitric oxide‐mediated mechanisms
(Wiley Blackwell Publishing, Inc, 2020-08)
Background and Purpose: The AT2 receptor plays a role in metabolism by opposing the actions triggered by the AT1 receptors. Activation of AT2 receptors has been shown to enhance insulin sensitivity in both normal and insulin ...
Insulin enhances leptin expression in human trophoblastic cells
(Oxford University Press, 2013-06)
Leptin, one of the adipokines that controls energy metabolism via the central nervous system, also has pleiotropic peripheral effects, acting as a proinflammatory cytokine. Leptin is also produced by trophoblastic cells ...
Diabetes-associated changes in the fetal insulin/insulin-like growth factor system are organ specific in rats
(Nature Publishing Group, 2015)