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Intrauterine programming of adult disease: Identification of cardinal genes associated with hypertension, obesity and metabolic syndromeProgramación intrauterina de enfermedad en la vida adulta: Identificación de genes cardinales asociados a hipertensión arterial, obesidad y síndrome metabólico
(Sociedad Argentina de Cardiologia, 2021-04)
Introducción: La restricción del crecimiento intrauterino es una alteración del desarrollo fetal que se caracteriza por una tasa de crecimiento durante la etapa fetal que es menor al potencial genético de crecimiento para ...
Enfermedad de Alzheimer y deterioro cognitivo asociado a la Diabetes Mellitus tipo 2: Relaciones e hipótesisAlzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
(Elsevier, 2014-11)
Introducción: Varios estudios epidemiológicos han demostrado que los pacientes de diabetes mellitus de tipo 2 presentan un aumento de riesgo para adquirir enfermedad de Alzheimer, pero las relaciones entre ellas no están ...
Grape pomace extract supplementation activates FNDC5/irisin in muscle and promotes white adipose browning in rats fed a high-fat diet
(Royal Society of Chemistry, 2020-01)
Irisin is a myokine regulated by peroxisome proliferator-activated receptor gamma co-activator-1α (PGC-1α) in the exercising skeletal muscle and released into the bloodstream after cleavage of FNDC5. Circulating irisin can ...
A novel heterozygous STAT5B variant in a patient with short stature and partial growth hormone insensitivity (GHI)
(Churchill Livingstone, 2020-02)
Background: The most frequent monogenic causes of growth hormone insensitivity (GHI) include defects in genes encoding the GH receptor itself (GHR), the signal transducer and activator of transcription (STAT5B), the insulin ...
The neuro-endocrine-immune relationship in pulmonary and pleural tuberculosis: A better local profile in pleural fluid
(International Union Against Tuberculosis and Lung Disease, 2018-03)
BACKGROUND: Tuberculosis (TB) is a major health problem worldwide. In TB, the immune and central nervous systems modulate each other. The two main components of this network are the hypothalamic-pituitary-adrenal axis (HPA) ...
Dietary restriction in sheep: Uterine functionality in ewes with different body reserves during early gestation
(Elsevier Science Inc, 2019-09)
The aim of this study was to characterize insulin, leptin and IGF-1 profiles after undernutrition in pregnant ewes with different initial body condition (iBCS) and to investigate embryo quality, uterine gene expression and ...
Quercetin attenuates adipose hypertrophy, in part through activation of adipogenesis in rats fed a high-fat diet
(Elsevier Science Inc, 2020-05)
An impaired capacity of adipose tissue expansion leads to adipocyte hypertrophy, inflammation and insulin resistance (IR) under positive energy balance. We previously showed that a grape pomace extract, rich in flavonoids ...