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Bone morphogenetic protein 15 and fibroblast growth factor 10 enhance cumulus expansion, glucose uptake, and expression of genes in the ovulatory cascade during in vitro maturation of bovine cumulus-oocyte complexes
(2013-07-01)
Oocyte-secreted factors (OSFs) regulate differentiation of cumulus cells and are of pivotal relevance for fertility. Bone morphogenetic protein 15 (BMP15) and fibroblast growth factor 10 (FGF10) are OSFs and enhance oocyte ...
Targeting the tumor extracellular matrix by the natural molecule 4-Methylumbelliferone: a complementary and alternative cancer therapeutic strategy
(Frontiers Media, 2021-10)
In antineoplastic therapy, one of the challenges is to adjust the treatment to the needs of each patient and reduce the toxicity caused by conventional antitumor strategies. It has been demonstrated that natural products ...
Expressão gênica da prolactina, do receptor de prolactina e das hialuronam síntases e a imunoistoquímica do ácido hialurônico e do receptor CD44 em úteros de camundongos fêmeas com hiperprolactinemia induzida pela metoclopramida, durante as fases do ciclo estral
(Universidade Federal de São Paulo (UNIFESP), 2011-04-27)
OBJECTIVE: To evaluate the gene expression of prolactin, prolactin receptor and hialuronan sintase and immunohistochemistry of hyaluronic acid and CD44 in the uterus of female mice with metoclopramide-induced hyperprolactinemia ...
Fibroblast growth factor 17 and bone morphogenetic protein 15 enhance cumulus expansion and improve quality of in vitro-produced embryos in cattle
(Elsevier B.V., 2015-08-01)
Bone morphogenetic protein 15 (BMP15) and members of the fibroblast growth factor (FGF) family are expressed by the oocyte and are involved in the control of cumulus cell function. We tested the hypothesis that FGF17, alone ...
Activation of β-catenin signaling in androgen receptor-negative prostate cancer cells
(American Association for Cancer Research, 2012-02)
Purpose: To study Wnt/β-catenin in castrate-resistant prostate cancer (CRPC) and understand its function independently of the β-catenin-androgen receptor (AR) interaction. Experimental Design: We carried out β-catenin ...
Microrganismos geneticamente modificados aplicados à biocatálise
(2021-07-30)
Biocatálise refere-se à utilização de enzimas ou células inteiras de microrganismos como
catalisadores em uma reação química representando uma rota sustentável para síntese de
químicos, principalmente devido à possibilidade ...
Regulação da expressão de fatores secretados pelo oócito (FSOs) e seus receptores durante a maturação in vitro (MIV) bovina e ações no controle da expressão de cumulus
(Universidade Estadual Paulista (Unesp), 2011-02-06)
O oócito participa ativamente dos mecanismos reguladores da maturação do complexo cumulus-oócito (COC) via secreção de fatores parácrinos. A proteína morfogênica óssea 15 (BMP15) e o fator de crescimento e diferenciação 9 ...