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Novel interactions of GRP78: UPR and estrogen responses in the brain
(Wiley, 2013-06)
Glucose-regulated protein 78 (GRP78; 78 kDa) belongs to a group of highly conserved heat shock proteins (Hsp) with important functions at the cellular level. The emerging interest for GRP78 relies on its different functions, ...
Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system
(Elsevier, 2014)
Progression of RNA interference-based gene silencing technologies for the treatment of disorders of the
central nervous system (CNS) depends on the availability of efficient non-toxic nanocarriers. Despite
advances in ...
Glyceraldehyde-3-phosphate dehydrogenase tetramer dissociation and amyloid fibril formation induced by negatively charged membranes
(Elsevier Science, 2010-02)
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional enzyme related with Huntington's, Parkinson's and Alzheimer's diseases. The ability of negatively charged membranes to induce a rapid formation of GAPDH ...
Nicotine Modulates Mitochondrial Dynamics in Hippocampal Neurons
(Humana Press, 2018-12)
Mitochondria are widely recognized as fundamental organelles for cellular physiology and constitute the main energy source for different cellular processes. The location, morphology, and interactions of mitochondria with ...
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration
(2021-05-05)
Alteration to endoplasmic reticulum (ER) proteostasis is observed in a variety of neurodegenerative diseases associated with abnormal protein aggregation. Activation of the unfolded protein response (UPR) enables an adaptive ...
Lack of Jun-N-terminal kinase 3 (JNK3) does not protect against neurodegeneration induced by 3-nitropropionic acid
(2012)
Aims: 3-Nitropropionic acid (3-NP) is a toxin that replicates most of the clinical and pathophysiological symptoms of Huntington's disease, inducing neurodegeneration in the striatum due to the inhibition of mitochondrial ...
Pattern diversity compact patch antenna
(2007)
A group of mutations characterized by trinucleotide repeat expansion causes human diseases such as the Fragile X syndrome, Huntington disease (HD), and myotonic dystrophy. Methods based on PCR amplification of the CGG and ...
Lack of Jun-N-terminal kinase 3 (JNK3) does not protect against neurodegeneration induced by 3-nitropropionic acid
(2012)
Aims: 3-Nitropropionic acid (3-NP) is a toxin that replicates most of the clinical and pathophysiological symptoms of Huntington's disease, inducing neurodegeneration in the striatum due to the inhibition of mitochondrial ...
Búsqueda de sitios de unión a ligandos en receptores nicotínicos de acetilcolina humano de tipo α7 y α4(2)β2(3)
(Universidad de Talca (Chile). Escuela de Bioinformática., 2014)