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Decreased production of TNF-alpha by lymph node cells indicates experimental autoimmune encephalomyelitis remission in Lewis rats
(Instituto Oswaldo Cruz, Ministério da Saúde, 2010-05-01)
Experimental autoimmune encephalomyelitis (EAE) is mediated by CD4+ Th1 cells that mainly secrete IFN-γ and TNF-α, important cytokines in the pathophysiology of the disease. Spontaneous remission is, in part, attributed ...
Resistance to experimental autoimmune encephalomyelitis development in Lewis rats from a conventional animal facility
(Instituto Oswaldo Cruz, Ministério da Saúde, 2007-12-01)
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the brain and spinal cord that is mediated by CD4+ T lymphocytes specific to myelin components. In this study we compared development of EAE in ...
Modulatory effects of tuberculosis vaccines on experimental autoimmune encephalomyelitis
(Universidade Estadual Paulista (UNESP), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP), 2014)
Stage-specific role of interferon-gamma in experimental autoimmune encephalomyelitis and multiple sclerosis
(Frontiers Media, 2015)
The role of interferon (IFN)-gamma in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), has remained as an enigmatic paradox for more than 30 years. Several studies attribute ...
Diazepam Inhibits Proliferation of Lymph Node Cells Isolated from Rats with Experimental Autoimmune Encephalomyelitis
(Karger, 2014-10)
Objective: Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease with similar-ities to human multiple sclerosis involving peripheral activa-tion of autoreactive T cells which infiltrate ...
Immunization with pVAXhsp65 Decreases Inflammation and Modulates Immune Response in Experimental Encephalomyelitis
(Karger, 2010-01-01)
Background: A DNA vaccine (pVAXhsp65) containing the gene of a heat-shock protein (hsp65) from Mycobacterium leprae showed high immunogenicity and protective efficacy against tuberculosis in BALB/c mice. A possible deleterious ...
Previous infection with Staphylococcus aureus strains attenuated experimental encephalomyelitis
(Biomed Central Ltd., 2014-01-09)
Background: Bacterial superantigens are potent T cell activators that can activate T cells with specificity for antigens of the central nervous system (CNS). In this study, we compared the effect of two S. aureus strains ...