Exon shuffling has been characterized as one of the major evolutionary forces shaping both the genome and the proteome of eukaryotes. This mechanism was particularly important in the creation of multidomain proteins during ...

Objective: In order to complete the knowledge of the genomic organization of the human thyroglobulin gene, the present work was designed to establish the intron-exon organization from exon 24 to exon 35 and to construct a ...

Background: Physical protein-protein interaction (PPI) is a critical phenomenon for the function of most proteins in living organisms and a significant fraction of PPIs are the result of domain-domain interactions. Exon ...

Schistosoma mansoni is the causative agent of Schistosomiasis, reaching 249 million people in 78 countries. It is believed that this infection is successful due to modulation of the host immune system through proteins ...

Hereditary myotonia caused by mutations in CLCN1 has been previously described in humans, goats, dogs, mice and horses. The goal of this study was to characterize the clinical, morphological and genetic features of hereditary ...

Hereditary myotonia caused by mutations in CLCN1 has been previously described in humans, goats, dogs, mice and horses. The goal of this study was to characterize the clinical, morphological and genetic features of hereditary ...

Determina la frecuencia de polimorfismos del exón 9 del gen metabolizador de fármacos CYP2D6 en pobladores peruanos. La finalidad del presente estudio es manejar las necesidades médicas justificadas y actuales, de igual ...

O gene de receptor B2 bradicinina de rato consiste de 4 exons separados por 3 introns, enquanto que o mesmo gene tem 3 exons separados por 2 introns em humanos e camundongo. Ha evidencias que ocorra splicing alternativo ...