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Essential roles of zebrafish rtn4/Nogo paralogues in embryonic development
(BMC, 2014)
Background: As a consequence of gene/genome duplication, the RTN4/Nogo gene has two counterparts in zebrafish: rtn4a and rtn4b. The shared presence of four specific amino acid motifs—M1 to M4—in the N-terminal region of ...
Validation of reference genes for gene expression studies in the honey bee, Apis mellifera, by quantitative real-time RT-PCR
(SPRINGER FRANCE, 2008)
For obtaining accurate and reliable gene expression results it is essential that quantitative real-time RT-PCR (qRT-PCR) data are normalized with appropriate reference genes. The current exponential increase in postgenomic ...
Essential regulatory elements for NHE3 gene transcription in renal proximal tubule cells
(Associação Brasileira de Divulgação Científica, 2011)
The objectives of the present study were to identify the cis-elements of the promoter absolutely required for the efficient rat NHE3 gene transcription and to locate positive and negative regulatory elements in the ...
Transcriptomic analysis and molecular docking reveal genes involved in the response of Aedes aegypti larvae to an essential oil extracted from Eucalyptus
(Public Library of Science, 2021-07)
Background: Aedes aegypti (L.) is an urban mosquito, vector of several arboviruses that cause severe diseases in hundreds of million people each year. The resistance to synthetic insecticides developed by Ae. aegypti ...
Characterization of a novel peroxisome membrane protein essential for conversion of isopenicillin N into cephalosporin C
(2010)
The mechanisms of compartmentalization of intermediates and secretion of penicillins and cephalosporins in β-lactam antibiotic-producing fungi are of great interest. In Acremonium chrysogenum, there is a compartmentalization ...
Paracoccidoides brasiliensis 30 kDa Adhesin: Identification as a 14-3-3 Protein, Cloning and Subcellular Localization in Infection Models
(2013-04-30)
Paracoccidoides brasiliensis adhesion to lung epithelial cells is considered an essential event for the establishment of infection and different proteins participate in this process. One of these proteins is a 30 kDa ...
Paracoccidoides brasiliensis 30 kDa Adhesin: Identification as a 14-3-3 Protein, Cloning and Subcellular Localization in Infection Models
(2013-04-30)
Paracoccidoides brasiliensis adhesion to lung epithelial cells is considered an essential event for the establishment of infection and different proteins participate in this process. One of these proteins is a 30 kDa ...
Subfunctionalization reduces the fitness cost of gene duplication in human by buffering dosage imbalances
(BioMed Central, 2011-12)
Background
Driven essentially by random genetic drift, subfunctionalization has been identified as a possible non-adaptive mechanism for the retention of duplicate genes in small-population species, where widespread ...
Leishmania: Overexpression and comparative structural analysis of the stage-regulated meta 1 gene
(Academic Press Inc, 1999-07-01)
The meta I gene of Leishmania major is upregulated in metacyclic promastigotes and encodes an 11.5-kDa protein with no significant similarities to other proteins in the existing databases. in this paper, we characterize ...
Physiological copper exposure in Jurkat cells induces changes in the expression of genes encoding cholesterol biosynthesis proteins
(Springer, 2013)
Copper is an essential micronutrient that
functions as an enzymatic cofactor in a wide range of
cellular processes. Although adequate Cu levels are
essential for normal metabolism, excess Cu can be
toxic to cells. ...