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Mostrando ítems 711-720 de 1852
Synthesis and evaluation of the trypanocydal activity of 4- alkylamino-6-nitroquinolines
(Freund Publishing House Ltd, 2000)
A straightforward synthesis of a group of 4-alkylamino-6-nitroquinolines starting from a common intermediate, 5,8-dimethoxy-6-nitro-4(1H)quinolone 3, is described. These compounds were tested in vitro as potential ...
A DPP study of ranitidine permeability
(1988)
The apparent permeation rate constants and amount of ranitidine transferred in 1 h were measured through everted rat intestine using a perfusion apparatus. The effects of pH and 5% or 10% ethanol on the apparent permeation ...
Quinacrine: sclerosing agent of the utero-tubal junction in women, with anticarcinogenic actions in transplanted tumors in mice
(1995)
Quinacrine, an acridine derivative that was in widespread use as an anti-malarial, has been shown to have both sclerosant and anticarcinogenic actions. The sclerosant action of quinacrine has been used to produce occlusion ...
Synthesis of a Novel Series of 4-Arylpiperazinyl Derivatives Linked to a 2-(Pyridin-3-yl)-1H-benzimidazole as New Delavirdine Analogues
(2010)
The synthesis of a series of substituted arylpiperazines linked to a 2-(pyridin-3-yl)-1H-benzo[d]imidazole scaffold through an alkylic linker is reported. The novel 1-(2-(4-arylpiperazin-1-yl)alkyl)-2-(pyridin-3-yl)-1H-b ...
Synergy between the antinociceptive effects of morphine and NSAIDs
(2004)
The intraperitoneal administration of morphine, diclofenac, ketoprofen, meloxicam, metamizol, paracetamol and piroxicam induced dose-dependent antinociception in mice tested with the acetic acid writhing test. The ...
Do antidepressants really increase suicide rates in childhood and adolescence? Es efectivo que los antidepresivos aumentan el riesgo de suicidio?
(2007)
The use of antidepressant in depressive illness results in a reduction of suicidal attempts and deaths due to suicide, conditions that are generally present in this disorder. Recently, the Federal Drug Administration (FDA) ...
Design and implementation of a high yield production system for recombinant expression of peptides
(Bio Med Central, 2014)
Making peptide pharmaceuticals involves challenging processes where many barriers, which include production and manufacture, need to be overcome. A non common but interesting research area is related to peptides with ...
Analysis of the opioid–opioid combinations according to the nociceptive stimulus in mice
(ELSEVIER, 2010)
The purpose of the present study was to characterize the antinociceptive effects of tramadol, fentanyl and
morphine,whentwoofthemwere systemically combined in a 1:1 potency ratio, in the hot plate, the acetic
acid writhing, ...
Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox
(AMER SOC MICROBIOLOGY, 2008)
L-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden ...
QUANTUM CHEMICAL STUDY OF ELECTRONIC-STRUCTURE AND RECEPTOR-BINDING IN OPIATES
(ELSEVIER SCIENCE BV, 1988)
A Quantitative Structure-Activity Relationship study for a group of opiates
interacting with the mu receptor was carried out. The study consisted in searching
a relationship between the drug-receptor equilibrium constant ...