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Advances in prodrug design
Sistemas para liberação colônica: Uma alternativa para a veiculação de fármacos para efeito local ou sistêmico
Problems related to the systemic administration of drugs, such as biodistribution, difficulty of targeting, necessity of high doses to achieve adequate levels of the drug in specific sites, toxicity, and undesirable side ...
The importance of bioactivation in computer-guided drug repositioning: Why the parent drug is not always enough
(Bentham Science Publishers, 2016-08)
Although bioactivation is a well-documented process and the role of active metabolites in the drug discovery field has long been recognized, drug metabolites are usually ignored in virtual screening campaigns oriented to ...
Validation of UV spectrophotometric method for determination of lomefloxacin in pharmaceutical dosage form
A simple and reproducible method was developed for the assay of lomefloxacin in tablets. The excipients in the commercial tablet preparation did not interfere with the assay. Beer's law is obeyed in the range 2.0-9.0 μg.mL-1 ...