Buscar
Mostrando ítems 31-40 de 1627
Using Computer-aided Drug Design and Medicinal Chemistry Strategies in the Fight Against Diabetes
(ADENINE PRESS, 2011)
The aim of this work is to present a simple, practical and efficient protocol for drug design, in particular Diabetes, which includes selection of the illness, good choice of a target as well as a bioactive ligand and then ...
Pharmacokinetic properties and in silico ADME modeling in drug discovery
(Bentham ScienceBussum, 2013-03)
The discovery and development of a new drug are time-consuming, difficult and expensive. This complex process has evolved from classical methods into an integration of modern technologies and innovative strategies addressed ...
Structure-based drug discovery for tropical diseases
(Bentham ScienceSharjah, 2009-06)
Parasitic diseases are amongst the foremost threats to human health and welfare around the world. In tropical and subtropical regions of the world, the consequences of parasitic infections are devastating both in terms of ...
Advances in drug design based on the amino acid approach: Taurine analogues for the treatment of CNS diseases
(2012-10-23)
Amino acids are well known to be an important class of compounds for the maintenance of body homeostasis and their deficit, even for the polar neuroactive aminoacids, can be controlled by supplementation. However, for the ...
Development of PEG-PCL-based polymersomes through design of experiments for co-encapsulation of vemurafenib and doxorubicin as chemotherapeutic drugs
(2022-03-01)
Nanostructures for co-encapsulation of chemotherapeutic drugs have been widely studied for the last years due to its important advantages, e.g. improved bioavailability and cellular uptake, increased solubility of drugs, ...
“Chameleonic” backbone hydrogen bonds in protein binding and as drug targets
(Springer, 2015-10-19)
We carry out a time-averaged contact matrix study to reveal the existence of protein backbone hydrogen bonds (BHBs) whose net persistence in time differs markedly form their corresponding PDB-reported state. We term such ...
Planejamento de fármacos, biotecnologia e química medicinal: Aplicações em doenças infecciosas
(2010-12-21)
Current drug design strategies are based on the understanding of the physiopathology of diseases, biochemical pathways and selection of molecular targets. Modern biotechnological tools have provided valuable information ...
Toxicidade de fármacos nitrofurânicos
(2008-12-01)
During the structural designing of new drugs, it is possible predict the influence of specific chemical groups on pharmacological activity. Among these, the nitro group has potential antiparasitic activity, being present ...
Carbon nanotubes buckypapers for potential transdermal drug delivery
(Elsevier Science, 2015-07)
Drug loaded buckypapers based on different types of carbon nanotubes (CNTs) were prepared and characterized in order to evaluate their potentialities for the design of novel transdermal drug delivery systems. Lab-synthesized ...