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Drug-loaded lipid-core micelles in mucoadhesive films as a novel dosage form for buccal administration of poorly water-soluble and biological drugs
(MDPI, 2020)
The aim of the study was to develop a novel buccal dosage form to transport rhodamine 123 and human insulin as models for poorly water-soluble and biological drugs, using lipid-core micelles (LCMs)-loaded mucoadhesive ...
Preface for buccal drug delivery theme issue
(Informa Healthcare, 2014)
During the past years, buccal drug delivery has attracted the attention of researchers looking for alternative delivery routes of administration. As an alternative to oral drug delivery, the buccal mucosal route avoids the ...
Development and Characterization of Florfenicol-Loaded BSA Nanoparticles as Controlled Release Carrier
(Springer New York LLC, 2019)
Florfenicol (FLO) is a broad-spectrum fluorinated antibiotic used for the treatment of bacterial diseases such as bovine respiratory disease (BRD) in cattle. FLO is a poorly soluble drug in aqueous solution, and its ...
Delivery of ionizable hydrophilic drugs based on pharmaceutical formulation of ion pairs and ionic liquids
(Elsevier, 2020)
New therapeutics such as antisense oligonucleotides, small interfering RNA and peptide-drug conjugates are taking great relevance in the pharmaceutical industry due to their specificity of action and their improved safety ...
Oxidative stress and neuroinflammation as a pivot in drug abuse. A focus on the therapeutic potential of antioxidant and anti-inflammatory agents and biomolecules
(MDPI, 2020)
Drug abuse is a major global health and economic problem. However, there are no pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse. Despite exerting different mechanisms of action, ...
Alternativas para la sanción y protección administrativa de consumidores de sustancias psicoactivas en Colombia : lecciones a partir de las experiencias de Estados Unidos y el Reino Unido con los tribunales de tratamiento de drogas.
(Universidad Catolica de Colombia, 2010-07-01)
La recientemente aprobada reforma del artículo 49 de la Constitución Política de Colombia estableció un régimen de sanción y protección administrativa para consumidores de drogas ilícitas en el país. Este artículo discute ...
Nanoantioxidant–Based silica particles as flavonoid carrier for drug delivery applications
(MDPI, 2020)
Nanosystems used in pharmaceutical formulations have shown promising results in enhancing the administration of drugs of difficult formulations. In particular, porous silica nanoparticles have demonstrated excellent ...
Alkylating Agents and Mouse Spermatogenesis: Effects of a Single Dose of Cyclophosphamide
(1985)
Summary: Cyclophosphamide (CFA) is one of the alkylating agents which has now been used with some success in the treatment of human neoplasias and renal disease. To evaluate how this drug could affect the seminiferous ...
Isobolographic analysis of the antinociceptive interactions of clonidine with nonsteroidal anti-inflammatory drugs
(ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2004-09)
The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the alpha(2)-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected ...
Dissolution kinetics evaluation of controlled-release tablets containing propranolol hydrochloride
(Marcel Dekker Inc., 1999)
In the present research, controlled-release propranolol hydrochloride tablets were prepared for twice-daily administration, allowing more uniform plasmatic levels of the drug. Pharmaceutical formulations were prepared with ...