Now showing items 11-20 of 242
Quantification of Doxycycline Hyclate in Tablets by HPLC-UV Method
(Oxford University Press, 2013-11-01)
An accurate, sensitive, precise and rapid gradient reversed-phase high-performance liquid chromatographic method was successfully developed and validated for the determination of doxycycline hyclate in bulk drug and tablets. ...
Increasing Doxycycline Hyclate Photostability by Complexation with beta-Cyclodextrin
Doxycycline hyclate (DOX) is a highly photosensitive drug, a feature that limits the stability of the corresponding dosage forms. The main objectives of this work were the preparation and characterization of an inclusion ...
Doxycycline Dose-dependently Inhibits MMP-2-Mediated Vascular Changes in 2K1C Hypertension
Hypertension induces vascular alterations that are associated with up-regulation of matrix metalloproteinases (MMPs). While these alterations may be blunted by doxycycline, a non-selective MMPs inhibitor, no previous study ...
Locally delivered doxycycline as an adjunctive therapy to scaling and root planing in the treatment of smokers: A clinical study
(Amer Acad PeriodontologyChicagoEUA, 2004)
Doxycycline ameliorates the dystrophic phenotype of skeletal and cardiac muscles in mdx mice
Evidence of early involvement of matrix metalloproteinase-2 in lead-induced hypertension
Lead exposure increases blood pressure (BP) by unknown mechanisms. Many recent studies have shown the involvement of matrix metalloproteinases (MMPs) in hypertension, particularly MMP-2. In this work, we have examined ...
Doxycycline ameliorates 2K-1C hypertension-induced vascular dysfunction in rats by attenuating oxidative stress and improving nitric oxide bioavailability
(ACADEMIC PRESS INC ELSEVIER SCIENCESAN DIEGO, 2012-03-31)
Vascular dysfunction associated with two-kidney, one-clip (2K-1C) hypertension may result from both altered matrix metalloproteinase (MMP) activity and higher concentrations of reactive oxygen species (ROS). Doxycycline ...