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Fatigue damage accumulation in aluminum 7050-T7451 alloy subjected to block programs loading under step-down sequence
(Elsevier B.V., 2010-01-01)
In this paper the fatigue damage accumulation under block program loading is investigated. Alternative flexion bending fatigue tests with a single change in stress amplitude are performed at room temperature for step-down ...
The role of tire size over the fatigue damage accumulation in vehicle bodies
(ElsevierAmsterdam, 2014)
One of the most important components related to vehicle dynamics is the tire and wheel set. According to their dimensions (diameter, height, width, design) the vehicle dynamic behavior and driving comfort are seriously ...
The role of mitochondrial DNA damage in the citotoxicity of reactive oxygen species
(SPRINGER/PLENUM PUBLISHERS, 2011)
Mitochondria contain their own genome, a small circular molecule of around 16.5 kbases. The mitochondrial DNA (mtDNA) encodes for only 13 polypeptides, but its integrity is essential for mitochondrial function, as all 13 ...
The sesquiterpene lactone dehydroleucodine triggers senescence and apoptosis in association with accumulation of DNA damage markers
(Public Library Of Science, 2013-01-14)
Sesquiterpene lactones (SLs) are plant-derived compounds that display anti-cancer effects. Some SLs derivatives have a marked killing effect on cancer cells and have therefore reached clinical trials. Little is known ...
Cell death induced by mitochondrial complex I inhibition is mediated by Iron Regulatory Protein 1
(Elsevier B.V., 2017)
© 2017 Elsevier B.V. Mitochondrial dysfunction and oxidative damage, often accompanied by elevated intracellular iron levels, are pathophysiological features in a number of neurodegenerative processes. The question arises ...
The RNA Response to DNA Damage
(Academic Press Ltd - Elsevier Science Ltd, 2016-06)
Multicellular organisms must ensure genome integrity to prevent accumulation of mutations, cell death, and cancer. The DNA damage response (DDR) is a complex network that senses, signals, and executes multiple programs ...