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A fluorescence nanoscopy marker for corticotropin-releasing hormone type 1 receptor: Computer design, synthesis, signaling effects, super-resolved fluorescence imaging, and: In situ affinity constant in cells
(Royal Society of Chemistry, 2018-11)
Class B G protein-coupled receptors (GPCRs) are involved in a variety of human pathophysiological states. These groups of membrane receptors are less studied than class A GPCRs due to the lack of structural information, ...
Direct effect of melatonin on Syrian Hamster testes: Mel1a receptors, inhibition on androgen production, and interaction with the local corticotropin-releasing hormone (CRH) system
(Endocrine Society, 2005-03-01)
Besides the hypothalamus and pituitary, melatonin action at the testicular level has been recently suggested. Therefore, we investigated in the Syrian hamster, a well-characterized seasonal breeder, melatonin action on ...
Sexual dimorphism of neuroendocrine-immune interactions
(Karger, 2002-12)
In the bidirectional interplay between the immune and endocrine systems, the communications most deeply investigated up to now have been those between the immuhC:and the hypothalamo-pituita~y-adrenal (HPA) and the HP-gonadal ...
Lifelong Aerobic Exercise Reduces the Stress Response in Rats
(Pergamon-Elsevier Science Ltd, 2018-04)
The aim of this study was to analyze the effects of lifelong aerobic exercise (AE) on the adaptive response of the stress system in rats. It is well known that hypothalamic–pituitary–adrenal axis (HPA) activity differs ...
Ghrelin Indirectly Activates Hypophysiotropic CRF Neurons in Rodents
(Public Library of Science, 2012-02)
Ghrelin is a stomach-derived hormone that regulates food intake and neuroendocrine function by acting on its receptor, GHSR (Growth Hormone Secretagogue Receptor). Recent evidence indicates that a key function of ghrelin ...
Methamphetamine Induces TET1- and TET3-Dependent DNA Hydroxymethylation of Crh and Avp Genes in the Rat Nucleus Accumbens
(Humana Press, 2017-08)
Methamphetamine (METH) addiction is a biopsychosocial disorder that is accompanied by multiple relapses even after prolonged abstinence, suggesting the possibilities of long-lasting maladaptive epigenetic changes in the ...
α-MSH and γ-MSH modulate early release of hypothalamic PGE2 and NO induced by IL-1β differently
(Elsevier Ireland, 2006-12)
Interleukin-1beta (IL-1beta) stimulates corticotropin-releasing hormone (CRH) secretion in hypothalamus, which involves the release of prostaglandins (PGE2) and nitric oxide (NO). We have demonstrated that melanocortins ...
Crosstalk of BMP-4 and RA signaling pathways on Pomc gene regulation in corticotrophs
(BioScientifica, 2019-10)
Retinoic acid (RA), an active metabolite of Vitamin A, and bone morphogenetic protein 4 (BMP-4) pathways control the transcription of pro-opiomelanocortin (Pomc), the precursor of ACTH. We describe a novel mechanism by ...
Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors
(Nature, 2018-12)
Stressful life events are primary environmental factors that markedly contribute to depression by triggering brain cellular maladaptations. Dysregulation of ventral tegmental area (VTA) dopamine neurons has been causally ...
The actions of ghrelin in the paraventricular nucleus: Energy balance and neuroendocrine implications
(Blackwell Publishing, 2019-04-22)
Ghrelin is a peptide mainly produced and secreted by the stomach. Since its discovery, the impact of ghrelin on the regulation of food intake has been the most studied function of this hormone; however, ghrelin affects a ...