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Immune complexes and apoptosis in B-cell chronic lymphocytic leukemia
(Taylor & Francis, 2002-02)
The progressive accumulation of B-cell chronic lymphocytic leukemia (B-CLL) cells in vivo is attributed to resistance to apoptosis, although this can be modulated in vitro by a variety of cellular and humoral factors ...
Specific components found in circulating immune complexes (CIC) in paracoccidioidomycosis
(1996-10-19)
Circulating immune complexes (CIC) from 15 paracoccidioidomycosis (PCM) patient sera and from 20 healthy control sera were analysed. After CIC precipitation, solubilization and acid treatment, only a little reactivity to ...
HPV16-associated tumors control myeloid cell homeostasis in lymphoid organs, generating a suppressor environment for T cells
(Federation Amer Soc Exp Biol, 2014-10-01)
Tumors are complex structures containing different types of cells and molecules. The importance of the tumor microenvironment in tumor progression, growth, and maintenance is well-established. However, tumor effects are ...
The IgA1 immune complex-mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy
(NATURE PUBLISHING GROUPNEW YORK, 2012)
IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, has significant morbidity and mortality as 20-40% of patients progress to end-stage renal disease within 20 years of onset. In order to gain ...
Phylodynamics and Dispersal of HRSV Entails Its Permanence in the General Population in between Yearly Outbreaks in Children
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
Background: Human respiratory syncytial virus (HRSV) is one of the major etiologic agents of respiratory tract infections among children worldwide. Methodology/Principal Findings: Here through a comprehensive analysis of ...
Anti-polymorphonuclear neutrophil antibodies in patients with leukopenia or neutropenia
(Wiley Blackwell Publishing, Inc, 2010-02)
Introduction: Immune humoral neutropenia (Np) could be the consequence of anti-polymorphonuclear neutrophil (PMN) antibodies, circulating immune complexes (CIC) and/or antibodies against myeloid precursors. Granulocyte ...
Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis
(2006-04-01)
The recent appreciation of the role played by endogenous counterregulatory mechanisms in controlling the outcome of the host inflammatory response requires specific analysis of their spatial and temporal profiles. In this ...
Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors
(Frontiers in Bioscience, 2009-01)
As a key component of the innate immune response, neutrophils play a major role in host protection against bacterial and fungi infections. Neutrophils are short-lived phagocytic cells and, as a first line of defense against ...
Desarrollo de vacunas contra el virus de la inmunodeficiencia humana tipo 1: relevancia de la inmunidad celular contra subtiposDevelopment of vaccines for HIV-1: relevance of subtype-specific cellular immunity
(Medicina (Buenos Aires), 2010-11)
Han pasado casi 30 años de la detección de los primeros casos de infección con HIV-1 y aún no se ha conseguido desarrollar una vacuna efectiva y segura. A pesar del impacto positivo sobre la pandemia que se ha conseguido ...
Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein
(American Heart AssociationDallas, 2013-06)
BACKGROUND:
Generation of active procoagulant cofactor factor Va (FVa) and its subsequent association with the enzyme activated factor X (FXa) to form the prothrombinase complex is a pivotal initial event in blood coagulation ...