Now showing items 21-30 of 46
Chromosomal integrity after UV irradiation requires FANCD2-mediated repair of double strand breaks
(Public Library of Science, 2016-01-14)
Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks ...
Concomitant tumor resistance: The role of tyrosine isomers in the mechanisms of metastases control
(American Association for Cancer Research, 2012-03)
Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. Although previous studies indicated that T-cell-dependent processes ...
The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA
(Celular Microbiology : 5(10), p. 695-707, 2003)
Among bacterial protein toxins, the cytolethal distending toxins (CDTs) are unique in their ability to activate the DNA damage checkpoint responses, causing cell cycle arrest or apoptosis in intoxicated cells. We provide ...
Combining immunotherapy with oncogene-targeted therapy: A new road for melanoma treatment
(Frontiers Research Foundation, 2015-02)
Cutaneous melanoma arises from the malignant transformation of skin melanocytes; its incidence and mortality have been increasing steadily over the last 50 years, now representing 3% of total tumors. Once melanoma metastasizes, ...
Human Papillomavirus (HPV), minireview and collateral expected benefits of the vaccine.
(Nepal Society of Obstetricians and Gynaecologists, 2019)
EIF2 kinases mediate β-lapachone toxicity in yeast and human cancer cells
(Landes Bioscience, 2015-02)
β-lapachone (β-lap) is a novel anticancer agent that selectively induces cell death in human cancer cells, by activation of the NQO1 NAD(P)H dehydrogenase and radical oxygen species (ROS) generation. We characterized the ...
Mecanismos da modulação da expressão de MHC II e CD86 em células dendríticas pela DNAK e a diminuição da rejeição em transplantes de pele
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
Dendritic cells (DCs) are the major antigen-presenting cells. They provide three main signals to fully activate T cells. Signal one is when the complex peptide:MHC (p:MHC) expressed by DC is recognized by T cell receptor; ...