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p53-Independent checkpoint controls in a plant cell model
(Sociedad de Biología de Chile, 2003)
uvsZ1 mutation shows epistatic relations with uvsD153 and uvsJ1 mutations without any involvement with checkpoint control in Aspergillus nidulans
(Sociedad de Biología de Chile, 2002)
Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis
(Elsevier, 2017-01)
Immune checkpoints, a plethora of inhibitory pathways aimed at maintaining immune cell homeostasis, may be co-opted by cancer cells to evade immune destruction. Therapies targeting immune checkpoints have reached a momentum ...
Roles of nibrin and ATM/ATR kinases on the G2 checkpoint under endogenous or radio-induced DNA damage
(Sociedad de Biología de Chile, 2005)
Immune checkpoints pathways in head and neck squamous cell carcinoma
(MDPI, 2021-03)
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors usually diagnosed at an advanced stage and characterized by a poor prognosis. The main risk factors associated with its development include ...
Hepatitis C Virus NS2 Protein Inhibits DNA Damage Pathway by Sequestering p53 to the Cytoplasm
(2013-04-30)
Chronic hepatitis C virus (HCV) infection is an important cause of morbidity and mortality globally, and often leads to end-stage liver disease. The DNA damage checkpoint pathway induces cell cycle arrest for repairing DNA ...
Hepatitis C Virus NS2 Protein Inhibits DNA Damage Pathway by Sequestering p53 to the Cytoplasm
(2013-04-30)
Chronic hepatitis C virus (HCV) infection is an important cause of morbidity and mortality globally, and often leads to end-stage liver disease. The DNA damage checkpoint pathway induces cell cycle arrest for repairing DNA ...
Role of inflammasome activation in tumor immunity triggered by immune checkpoint blockers
(Wiley Blackwell Publishing, Inc, 2020-03)
Immune checkpoint blockers improve the overall survival of a limitednumber of patients among different cancers. Identifying pathways thatinfluence the immunological and clinical response to treatment is criticalto improve ...