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Germ cells regulate 3-hydroxybutyrate production in rat Sertoli cells
(Academic Press Inc Elsevier Science, 2017-04)
Paracrine regulation of Sertoli cell function by germ cells is an outstanding characteristic of testicular physiology. It has been demonstrated that Sertoli cells produce ketone bodies and that germ cells may use them as ...
Combination of stem cells and rehabilitation therapies for ischemic stroke
(MDPI, 2021-09-01)
Stem cell transplantation with rehabilitation therapy presents an effective stroke treatment. Here, we discuss current breakthroughs in stem cell research along with rehabilitation strategies that may have a synergistic ...
A simplified approach for efficient isolation of functional microglial cells: Application for modeling neuroinflammatory responses in vitro
(Wiley-liss, Div John Wiley & Sons Inc, 2016-11)
Purified microglial cells in culture are frequently used to model brain inflammatory responses but obtaining large yields of these cells on a routine basis can be quite challenging. Here, we demonstrate that it is possible ...
Altered phenotype and functionality of circulating immune cells characterize adult patients with nonalcoholic steatohepatitis
(Springer/Plenum Publishers, 2011-08-17)
Nonalcoholic steatohepatitis (NASH) is a chronic inflammatory liver disease associated with insulin resistance and its metabolic consequences. Leukocyte mobilization, intrahepatic activation, and an exacerbated production ...
Direct effect of dsRNA mimetics on cancer cells induces endogenous IFN-β production capable of improving dendritic cell function
(Wiley VCH Verlag, 2013-05)
Viral double-stranded RNA (dsRNA) mimetics have been explored in cancer immunotherapy to promote antitumoral immune response. Polyinosine–polycytidylic acid (poly I:C) and polyadenylic–polyuridylic acid (poly A:U) are ...
Are Glial Cells Critical Participants in Brain Development, Function, and Disease?
(OMINCS, 2012-09)
Recently, an increasing number of studies have implicated a third element in plasticity; the perisynaptic glial cell. Originally glial cells were thought to be important for metabolic maintenance and support of Central The ...
Update on the Functionality of Thymic Stromal Lymphopoietin and its Interaction with Dendritic Cells, to Trigger a Pro or Anti-Inflammatory Status
(SciTech Central Inc., 2020-11)
Thymic stromal lymphopoietin (TSLP) is a cytokine produced primarily by activated epithelial cells of the lung, skin and intestine. The foremost property of this cytokine is to condition dendritic cells (DC) to initiate ...
Expansion of CD11b+Ly6G +Ly6Cint cells driven by medroxyprogesterone acetate in mice bearing breast tumors restrains NK cell effector functions
(Springer, 2013-10-11)
The progesterone analog medroxyprogesterone acetate (MPA) is widely used as a hormone replacement therapy in postmenopausal women and as contraceptive. However, prolonged administration of MPA is associated with increased ...
Characterization and functionality of proliferative human sertoli cells
(Cognizant Communication Corp, 2011-05)
It has long been thought that mammalian Sertoli cells are terminally differentiated and nondividing postpuberty. For most previous in vitro studies immature rodent testes have been the source of Sertoli cells and these ...
Neutrophils suppress γδ T-cell function
(Wiley VCH Verlag, 2013-12)
γδ T cells have been shown to stimulate the recruitment and activation of neutrophils through the release of a range of cytokines and chemokines. Here, we investigated the reverse relationship, showing that human neutrophils ...