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Are Glial Cells Critical Participants in Brain Development, Function, and Disease?
(OMINCS, 2012-09)
Recently, an increasing number of studies have implicated a third element in plasticity; the perisynaptic glial cell. Originally glial cells were thought to be important for metabolic maintenance and support of Central The ...
Update on the Functionality of Thymic Stromal Lymphopoietin and its Interaction with Dendritic Cells, to Trigger a Pro or Anti-Inflammatory Status
(SciTech Central Inc., 2020-11)
Thymic stromal lymphopoietin (TSLP) is a cytokine produced primarily by activated epithelial cells of the lung, skin and intestine. The foremost property of this cytokine is to condition dendritic cells (DC) to initiate ...
Expansion of CD11b+Ly6G +Ly6Cint cells driven by medroxyprogesterone acetate in mice bearing breast tumors restrains NK cell effector functions
(Springer, 2013-10-11)
The progesterone analog medroxyprogesterone acetate (MPA) is widely used as a hormone replacement therapy in postmenopausal women and as contraceptive. However, prolonged administration of MPA is associated with increased ...
Characterization and functionality of proliferative human sertoli cells
(Cognizant Communication Corp, 2011-05)
It has long been thought that mammalian Sertoli cells are terminally differentiated and nondividing postpuberty. For most previous in vitro studies immature rodent testes have been the source of Sertoli cells and these ...
Neutrophils suppress γδ T-cell function
(Wiley VCH Verlag, 2013-12)
γδ T cells have been shown to stimulate the recruitment and activation of neutrophils through the release of a range of cytokines and chemokines. Here, we investigated the reverse relationship, showing that human neutrophils ...
Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function
(Wiley VCH Verlag, 2008-11)
Galectin-1 has been implicated in regulating T-cell survival, function, and Th1/Th2 balance in several mouse models, though the molecular and cellular basis of its immunomodulatory activity has not been completely ...
CXCL12 is a costimulator for CD4+ T cell activation and proliferation in chronic lymphocytic leukemia patients
(Springer, 2013-01)
Activated T cells from patients with chronic lymphocytic leukemia (CLL) provide survival and proliferative signals to the leukemic clone within lymphoid tissues. Recruitment of both, CLL cells and T lymphocytes, to this ...
Curcumin inhibits the growth, induces apoptosis and modulates the function of pituitary folliculostellate cells
(Karger, 2010-03)
The polyphenol curcumin (diferuloylmethane) is the active componenet of the spice plant Curcuma longa and has been shown to exert multiple actions on mammalian cells. We have studied its effect on folliculostellate (FS) ...
Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance
(Wiley Blackwell Publishing, Inc, 2019-06-23)
In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (or tumor-initiating cells) is characterized by self-renewal, unlimited proliferative potential, expression of multidrug-resistance ...
Regulatory Dendritic Cells restrain NK cell IFN-g production through mechanisms involving NKp46, IL-10 and MHC class I-specific inhibitory receptors
(Amer Assoc Immunologists, 2015-09-01)
Cross-talk between mature dendritic cells (mDC) and NK cells through the cell surface receptors NKp30 and DNAM-1 leads to their reciprocal activation. However, the impact of regulatory dendritic cells (regDC) on NK cell ...