Now showing items 41-50 of 952
Effects of early aldosterone antagonism on cardiac remodeling in rats with aortic stenosis-induced pressure overload
Aldosterone plays a pivotal role in the pathophysiology of systolic heart failure. However, whether early aldosterone antagonism improves cardiac remodeling during persistent pressure overload is unsettled. We evaluated ...
SH Oxidation Stimulates Calcium Release Channels (Ryanodine Receptors) from Excitable Cells
(Society of Biology of Chile, 2000)
The effects of redox reagents on the activity of the intracellular calcium release channels (ryanodine receptors) of skeletal and cardiac muscle, or brain cortex neurons, was examined. In lipid bilayer experiments, oxidizing ...
Mitochondria, myocardial remodeling, and cardiovascular disease
The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy
There still controversy about the relation between changes in myocardial contractile function and global left ventricular (LV) performance during stable concentric hypertrophy. To clarify this, we analyzed LV function in ...
Mitochondrial dynamics, mitophagy and cardiovascular disease
Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or myocardial injury, and allows the heart to meet an increased demand for oxygen. Although initially beneficial, hypertrophy can ...
Myostatin and follistatin expression in skeletal muscles of rats with chronic heart failure
(Wiley-Blackwell Publishing, Inc, 2014)
Myosin heavy chain expression and atrophy in rat skeletal muscle during transition from cardiac hypertrophy to heart failure
(International Journal Of Experimental Pathology, 2015)
Hypertrophied myocardium is more dependent on extracellular calcium than the normal cardiac muscle
Background: The aim of this study was to analyze stable hypertrophied myocardial function and its response to inotropic maneuvers in rats submitted to renovascular hypertension for a 10-week period (RHT group, n=10). ...