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Snake venomics of the Siamese Russell's viper (Daboia russelli siamensis) - Relation to pharmacological activities
(Elsevier B.V., 2009-03-06)
The venom proteome of Daboia russelli siamensis, a snake of medical importance in several Asian countries, was analysed by 2-D electrophoresis, subsequent MS/MS and enzymatic assays. The proteome comprises toxins from six ...
Biochemical and functional properties of a thrombin-like enzyme isolated from Bothrops pauloensis snake venom
(Pergamon-Elsevier B.V. Ltd, 2009-11-01)
In the present study, a thrombin-like enzyme named BpSP-I was isolated from Bothrops pauloensis snake venom and its biochemical, enzymatic and pharmacological characteristics were determined. BpSP-I is a glycoprotein that ...
Proteinase inhibitors in Brazilian leguminosae
(Instituto Oswaldo Cruz, Ministério da Saúde, 1991-01-01)
Serine proteinase inhitors, in the seeds of several Leguminosae from the Pantanal region (West Brazil), were studied using bovine trypsin, a digestive enzyme, Factor XIIa and human plasma Kallikrein, two blood clotting ...
Glycosaminoglycans affect the interaction of human plasma kallikrein with plasminogen, factor XII and inhibitors
(Associação Brasileira de Divulgação Científica, 2003-08-01)
Human plasma kallikrein, a serine proteinase, plays a key role in intrinsic blood clotting, in the kallikrein-kinin system, and in fibrinolysis. The proteolytic enzymes involved in these processes are usually controlled ...
Heparin modulation of human plasma kallikrein on different substrates and inhibitors
(Walter de Gruyter & Co, 2006-08-01)
The interplay of different proteases and glycosaminoglycans is able to modulate the activity of the enzymes and to affect their structures. Human plasma kallikrein ( huPK) is a proteolytic enzyme involved in intrinsic blood ...
Influence of the ratio of particulate autogenous bone graft/platelet-rich plasma on bone healing in critical-size defects: a histologic and histometric study in rat calvaria
(John Wiley & Sons Inc, 2010-04-01)
The purpose of this study was to analyze histomorphometrically the influence of the ratio of particulate autogenous bone (AB) graft/platelet-rich plasma (PRP) on bone healing in surgically created critical-size defects ...
Bone healing in critical-size defects treated with platelet-rich plasma: a histologic and histometric study in rat calvaria
(Blackwell Publishing, 2008-04-01)
Background and objective: The purpose of this study was to analyze histologically the influence of autologous platelet-rich plasma on bone healing in surgically created critical-size defects in rat calvaria.Material adn ...
Effect of platelet-rich plasma on bone healing of autogenous bone grafts in critical-size defects
(Wiley-Blackwell Publishing, Inc, 2009-09-01)
AimThis study histologically analysed the effect of autogenous platelet-rich plasma (PRP), prepared according to a new semiautomatic system, on healing of autogenous bone (AB) grafts placed in surgically created critical-size ...
Influence of the proportion of particulate autogenous bone graft/platelet-rich plasma on bone healing in critical-size defects: An immunohistochemical analysis in rat calvaria
(Elsevier B.V., 2009-08-01)
This immunohistochemical analysis evaluated the influence of the proportion of particulate autogenous bone (AB) graft/platelet-rich plasma (PRP) on bone healing in surgically created critical-size defects (CSD) in rat ...
Platelet lysate 3D scaffold supports mesenchymal stem cell chondrogenesis: An improved approach in cartilage tissue engineering
(2013-04-08)
Articular lesions are still a major challenge in orthopedics because of cartilage's poor healing properties. A major improvement in therapeutics was the development of autologous chondrocytes implantation (ACI), a ...