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Structural and functional characterization of myotoxin I, a Lys49 phospholipase A(2) homologue from Bothrops moojeni (Caissaca) snake venom
(Academic Press Inc., 2000-01-01)
Myotoxin-I (MjTX-I) was purified to homogeneity from the venom of Bothrops moojeni by ion-exchange chromatography on CM-Sepharose. Its molecular weight, estimated by SDS-PAGE, was 13,400 (reduced) or 26,000 (unreduced). ...
Intracranial and systemic atherosclerosis in the NAVIGATE ESUS trial: Recurrent stroke risk and response to antithrombotic therapy
(2020)
Non-stenotic intracranial and systemic atherosclerosis are associated with ischemic stroke. We report frequency and response to anticoagulant vs. antiplatelet prophylaxis of patients with embolic stroke of undetermined ...
Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation
(Multidisciplinary Digital Publishing Institute (MDPI), 2019)
Hypercoagulable state is linked to cancer progression; however, the precise role of the coagulation cascade is poorly described. Herein, we examined the contribution of a hypercoagulative state through the administration ...
Evaluación in vivo de la actividad anticoagulante de polisacáridos sulfatados extraidos del alga Macrocystis pyrifera
(2016-08-22)
Las algas contienen varios fucanos y galactanos sulfatados que presentan actividad anticoagulante y es importante determinar si estas moléculas generan efectos secundarios a largo plazo. En el presente trabajo se evaluó ...
Estudo de métodos cromatográficos, eletroforético e biológicos in vitro para análise de rivaroxabana
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2019-08-21)
Rivaroxaban (RIV) is an oral anticoagulant with the mechanism of action based on the inhibition of the factor Xa of the coagulation cascade. It is clinically used for the prophylaxis and treatment of thromboembolic diseases ...
Análisis mutacional del factor v de leiden, protrombina g20210a y metilentetrahidrofolato reductasa c677t y a1298c en una muestra de pacientes con susceptibilidad a trombofilia
(2011)
La trombosis es una de las principales causas de mortalidad y morbilidad en el mundo aumentando de 1 por 100000 personas durante la infancia a 1 por 100 personas en los adultos mayores con una evidencia que demuestra la ...
Tratamiento odontológico a pacientes con prótesis valvular cardiaca
(Universidad de Guayaquil. Facultad Piloto de Odontología, 2014-07)
Los pacientes con prótesis valvulares cardiacas suelen presentar riesgos durante la atención odontológica, entre los que suelen ser muy frecuentes la endocarditis bacteriana y las hemorragias. Podríamos decir que la ...
Spontaneous perforation of the bile duct in a neonate. An unexpected finding. Case report
(2017)
La perforación espontánea de la vía biliar extrahepática es rara en recién nacidos. Es una causa quirúrgica de ictericia en este período y la presentación aguda es inusual. Objetivo: presentar un caso de perforación ...
Structural and functional characterization of myotoxin I, a Lys49 phospholipase A(2) homologue from Bothrops moojeni (Caissaca) snake venom
(2000-01-01)
Myotoxin-I (MjTX-I) was purified to homogeneity from the venom of Bothrops moojeni by ion-exchange chromatography on CM-Sepharose. Its molecular weight, estimated by SDS–PAGE, was 13,400 (reduced) or 26,000 (unreduced). ...
Myotoxic phospholipases A2 in Bothrops snake venoms: Effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu
(2000-08)
Venoms from eight Bothrops spp. were fractionated by ion-exchange chromatography on CM-Sepharose at pH 8.0 for the purification of myotoxins. Chromatographic profiles showed differences regarding myotoxic components among ...