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Mostrando ítems 21-30 de 1920
Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes
(Bentham Science Publishers, 2002-04)
Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism ...
Conformational and stereoeletronic investigations of muscarinic agonists of acetylcholine by NMR and theoretical calculations
(Elsevier Science BvAmsterdamHolanda, 2012)
In silico characterization of cytisinoids docked into an acetylcholine binding protein
(PERGAMON-ELSEVIER SCIENCE LTD, 2010-05-06)
Homology models of nicotinic acetylcholine receptors (nAChRs) suggest that subtype specificity is due to
non-conserved residues in the complementary subunit of the ligand-binding pocket. Cytisine and its
derivatives ...
Acetylcholine from visual circuits modulates the activity of arousal neurons in Drosophila
(Society for Neuroscience, 2015-12)
Drosophila melanogaster’s large lateral ventral neurons (lLNvs) are part of both the circadian and sleep-arousal neuronal circuits. In the past, electrophysiological analysis revealed that lLNvs fire action potentials (APs) ...
Electrophysiological characterization of nicotinic acetylcholine receptors in cat petrosal ganglion neurons in culture: Effects of cytisine and its bromo derivatives
(ELSEVIER, 2006-02-09)
Petrosal ganglion neurons are depolarized and fire action potentials in response to acetylcholine and nicotine. However, little is known about the subtype(s) of nicotinic acetylcholine receptors involved, although alpha 4 ...
Neuronal nicotinic acetylcholine receptor-cholesterol crosstalk in Alzheimer's disease
(Elsevier Science, 2010-05-03)
Alzheimer’s disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied ...
Melatonin and the time window for the expression of the alpha 8 nicotinic acetylcholine receptor in the membrane of chick retinal cells in culture
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
We have previously shown that melatonin influences the development of alpha 8 nicotinic acetylcholine receptor (nAChR) by measurement of the acetylcholine-induced increase in the extracellular acidification rate (ECAR) in ...