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Beta-Amyloid Oligomers Affect the Structure and Function of the Postsynaptic Region: Role of the Wnt Signaling Pathway.
(2008)
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. Synaptic dysfunction is an early manifestation of AD. The cellular mechanism by which beta-amyloid peptide ...
Wnt5a promotes differentiation and development of adult-born neurons in the hippocampus by noncanonical Wnt signaling
(2020-03-01)
In the adult hippocampus, new neurons are generated in the dentate gyrus. The Wnt signaling pathway regulates this process, but little is known about the endogenous Wnt ligands involved. We investigated the role of Wnt5a ...
Non-canonical Wnt signalling and regulation of gastrulation movements
(Elsevier Ltd, 2002)
Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt ...
The Role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease.
(2008)
Recent evidence supports a neuroprotective role for Wnt signaling in neurodegenerative disorders such as Alzheimer's Disease (AD). In fact, a relationship between amyloid-beta-peptide (Abeta)-induced neurotoxicity and a ...
Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway
(2009)
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) plays a key role in the regulation of calcium-dependent gene expression. The expression of CaMKIV and the activation of CREB regulated genes are involved in memory ...
El receptor Ror1 y su rol en cancerThe role of Ror1 receptor in cancerO receptor Ror1 e seu papel em câncer
(Federación Bioquímica de la Provincia Buenos Aires, 2011-12)
Las proteínas Wnt son ligandos que activan señales involucradas en proliferación, sobrevida, adhesión, migración, diferenciación y polaridad celular y como tal están involucradas en una amplia variedad de patologías. A ...
The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment
(Springer, 2020-05-20)
Wnt5a is the prototypical activator of the non-canonical Wnt pathways, and its overexpression has been implicated in the progression of several tumor types by promoting cell motility, invasion, EMT, and metastasis. Recent ...
Signaling network involved in the GPC3-induced inhibition of breast cancer progression: role of canonical Wnt pathway
(Springer, 2018-09)
Purpose: We have shown that GPC3 overexpression in breast cancer cells inhibits in vivo tumor progression, by acting as a metastatic suppressor. GPC3-overexpressing cells are less clonogenic, viable and motile, while their ...
CNBP modulates the transcription of Wnt signalling pathway components.
(Elsevier Science, 2014-08)
Background: Cellular nucleic acid binding protein (CNBP) is a small and highly conserved protein with nucleic acid chaperone activity that binds single-stranded nucleic acids. Data collected so far suggests that CNBP is ...