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Photochemistry of tyrosine dimer: when an oxidative lesion of proteins is able to photoinduce further damage
(Royal Society of Chemistry, 2019-04)
The tyrosine dimer (Tyr2), a covalent bond between two tyrosines (Tyr), is one of the most important modifications of the oxidative damage of proteins. This compound is increasingly used as a marker of aging, stress and ...
Structural and electronic properties of tyrosine kinases inhibitors
(C M B Association, 2003-09)
Protein tyrosine kinases (TKs) regulate cell proliferation, cell differentiation, and play a fundamental role in signal transduction pathway. Uncontrolled signaling from receptor tyrosine kinases and intracellular tyrosine ...
Specific tyrosine phosphorylation of α7 nicotinic receptor modulates its ionotropic and metabotropic responses
(Sociedad Argentina de Neurociencias, 2020)
Angiotensin-(1-7) through AT2 receptors mediates tyrosine hydroxylase degradation via the ubiquitin-proteasome pathway
(Wiley Blackwell Publishing, Inc, 2009-01)
Hypothalamic norepinephrine (NE) release regulates arterial pressure by altering sympathetic nervous system activity. Because angiotensin (Ang) (1-7) decreases hypothalamic NE release and this effect may be correlated with ...
Evidence for the involvement of Proline-rich Tyrosine Kinase 2 (PYK2) in tyrosine phosphorylation downstream of PKA activation during human sperm capacitation
(Oxford University Press, 2014-09-01)
Sperm capacitation involves an increase in intracellular Ca(2+) concentration as well as in protein kinase A (PKA)-dependent protein tyrosine (Tyr) phosphorylation. Interestingly, in humans, a decrease in extracellular ...
Tyrosine phosphorylation signalling dependent on 1α,25(OH) 2-vitamin D3 in rat intestinal cells: Effect of ageing
(Pergamon-Elsevier Science Ltd, 2004-12)
In intestinal cells, as in other target cells, 1α,25(OH) 2D3 elicits long-term and short-term responses which involve genomic and non-genomic mode of actions, respectively. There is evidence indicating that activation of ...
Meta-tyrosine modulates the immune response induced by bacterial endotoxins
(Elsevier Gmbh, 2019-10)
The effectiveness of both, trials aimed at counteracting the sepsis-associated inflammation and anti-tumor vaccines has, up to date, been limited. These limitations may be related to the fact that in sepsis and cancer, the ...
Exploring the molecular basis of human manganese superoxide dismutase inactivation mediated by tyrosine 34 nitration
(Elsevier Science Inc, 2011-03)
Manganese Superoxide Dismutase (MnSOD) is an essential mitochondrial antioxidant enzyme that protects organisms against oxidative damage, dismutating superoxide radical (O2-) into H2O2 and O2. The active site of the protein ...
Unraveling the effects of peroxiredoxin 2 nitration; role of C-terminal tyrosine 193
(Elsevier Science Inc., 2019-09)
Peroxiredoxins (Prx) are enzymes that efficiently reduce hydroperoxides through active participation of cysteine residues (CP, CR). The first step in catalysis, the reduction of peroxide substrate, is fast, 107 - 108 M−1s−1 ...
Oxygen uptake in the vitamin B2-sensitized photo-oxidation of tyrosine and tryptophan in the presence of uracil: Kinetics and mechanism
(Wiley Blackwell Publishing, Inc, 2009-09)
Considering the significance of visible light-promoted reactions in complex biological media, the photo-oxidation of the amino acids (AAs) tyrosine (tyr) and tryptophan (trp) was studied in the presence of the naturally ...