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A2B adenosine receptor enhances chemoresistance of glioblastoma stem-like cells under hypoxia: new insights into MRP3 transporter function
(MDPI, 2022)
Glioblastoma is the most common and aggressive primary brain tumor, characterized
by its high chemoresistance and the presence of a cell subpopulation that persists under hypoxic
niches, called glioblastoma stem-like ...
Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment
(Oxford University Press, 2014-08-12)
Abnormal glycosylation is a typical hallmark of the transition from healthy to neoplastic tissues. Although the importance of glycans and glycan-binding proteins in cancer-related processes such as tumor cell adhesion, ...
Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis in Kaposi's sarcoma
(Rockefeller Univ Press, 2012-10)
Kaposi’s sarcoma (KS), a multifocal vascular neoplasm linked to human herpesvirus-8 (HHV-8/KS-associated herpesvirus [KSHV]) infection, is the most common AIDS-associated malignancy. Clinical management of KS has proven ...
Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: glycans make the difference
(Landes Bioscience, 2014-06-25)
Although blocking vascular endothelial growth factor (VEGF) signaling is clinically beneficial in certain cancers, tumor regrowth in treated patients suggests that compensatory angiogenic programs may limit the efficacy ...
Caveolin-1-mediated tumor suppression is linked to reduced hif1α s-nitrosylation and transcriptional activity in hypoxia
(2020-09)
Caveolin-1 (CAV1) is a well-established nitric oxide synthase inhibitor, whose function as a tumor suppressor is favored by, but not entirely dependent on, the presence of E-cadherin. Tumors are frequently hypoxic and the ...
The hypoxic microenvironment induces stearoyl-coa desaturase-1 overexpression and lipidomic profile changes in clear cell renal cell carcinoma
(MDPI, 2021-06)
Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal cell carcinoma (RCC). It is characterized by a high cell proliferation and the ability to store lipids. Previous studies have ...
Activation of STAT3 by hypoxia in in vitro models of cervical cancer and endothelial cells
The biological behavior of cancer cells is influenced by the tumor microenvironment in which they develop. In this context, stressor stimuli such as hypoxia are considered critical for tumor development and therapeutic ...
Classification of brain tumor extracts by high resolution H-1 MRS using partial least squares discriminant analysis
(Assoc Bras Divulg CientificaSao PauloBrasil, 2011)
Part-time cancers and role of melatonin in determining their metabolic phenotype
(2021-08-01)
This brief review describes the association of the endogenous pineal melatonin rhythm with the metabolic flux of solid tumors, particularly breast cancer. It also summarizes new information on the potential mechanisms by ...