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Involvement of KLF14 and egr-1 in the TGF-beta1 action on Leydig cell proliferation
(Academic Press Ltd - Elsevier Science Ltd, 2013-02)
Transforming growth factor β1 (TGF-β1) is a pleiotropic cytokine that modulates cell homeostasis. In Leydig cells, TGF-β1 exerts stimulatory and inhibitory effect depending on the type I receptor involved in the signaling ...
d-glucose increased l-arginine transport and nitric oxide synthesis through an autocrine mechanism involving TGF-β1 and TGF-β receptor II (TβRII) in human umbilical vein endothelium
(2006)
High D-glucose increases L-arginine transport, nitric oxide (NO) synthesis, and release of Transforming Growth Factor β1 (TGF-β1) in human umbilical vein endothelium (HUVEC). Changes in cell proliferation in response to ...
Transforming growth factor-beta and Forkhead box O transcription factors as cardiac fibroblast regulators
(IRCA-BSSA, 2017)
Fibroblasts play several homeostatic roles, including electrical coupling, paracrine signaling and tissue repair after injury. Fibroblasts have low secretory activity. However, in response to injury, they differentiate to ...
Adenoviral delivery of dominant-negative transforming growth factor β type II receptor up-regulates transcriptional repressor SKI-like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats
(2009)
Background: Dominant-negative transforming growth factor β type II receptor (TβRIIΔcyt) is a protein that blocks transforming growth factor (TGF-β) signaling. Because the consequences of blocking TGF-β have not been ...
VIP and tolerance induction in autoimmunity
(Blackwell Publishing, 2006-12)
Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with ...
Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-β signaling
(2007)
The endothelial nitric oxide synthase (eNOS) is a critical regulator of cardiovascular homeostasis, whose dysregulation leads to different vascular pathologies. Endoglin is a component of the transforming growth factor ...
Amplified expression of dominant-negative transforming growth factor-beta type II receptor inhibits collagen type I production via reduced Smad-3 activity
(2004)
Background and Aim: As a pleiotropic protein, transforming growth factor (TGF)-β induces its effects by binding to its Ser/Thr kinase receptor type II and then recruiting and activating receptor type I, which is phosphorylated ...
Structural, cytochemical, immunocytochemical and ultrastructural characterization of blood granulocytes of the roadside hawk Buteo magnirostris (Gmelin, 1788) (Avian, Falconiform)
(2003-10-01)
In the peripheral blood of the roadside hawk, Buteo magnirostris, the following types of granulocytic leucocytes were identified: heterophil, eosinophil and basophil. The heterophils presented acidophilic and spindle shaped ...
Structural, cytochemical, immunocytochemical and ultrastructural characterization of blood granulocytes of the roadside hawk Buteo magnirostris (Gmelin, 1788) (Avian, Falconiform)
(2003-10-01)
In the peripheral blood of the roadside hawk, Buteo magnirostris, the following types of granulocytic leucocytes were identified: heterophil, eosinophil and basophil. The heterophils presented acidophilic and spindle shaped ...