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Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL) -17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis
(John Wiley & Sons, 2009-05)
Aim: T regulatory (Treg) cells have been detected in periodontitis lesions, and forkhead box P3 (Foxp3) expression has been negatively correlated to receptor activator of nuclear factor-κ B ligand (RANKL). The aim of this ...
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation.
(2013-07-08)
Growth factors, insulin signaling and nutrients are important regulators of β-cell mass and function. The events linking these
signals to regulation of β-cell mass are not completely understood. Recent findings indicate ...
Anti-fibrotic effect of mycophenolate mofetil on Peyronie’s disease experimentally induced with TGF-β
(2019-01-01)
The aim of the present study was to evaluate the histological, histochemical, and stereological changes caused by mycophenolate mofetil (MMF) on the tunica albuginea of rat penises submitted to an injection of transforming ...
Melatonin treatment combined with TGF-β silencing inhibits epithelialmesenchymal transition in CF41 canine mammary cancer cell line
(2020-01-01)
Background: Mammary cancer is the most prevalent type of cancer in female dogs. The main cause of mortality is the occurrence of metastasis. The metastatic process is complex and involves the EpithelialMesenchymal Transition ...
The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1
(Academic Press Inc Elsevier Science, 2010-03)
We previously reported that paediatric (PAH) and adult (AAH) forms of type I autoimmune hepatitis (AH) have different HLA-associations and clinical outcome. In the present study we investigated the role of TGF-β1 genetic ...
Influence of the photoperiod on TGF-β1 and p15 expression in hamster Leydig cells
(Inst Animal Reproduction Food Research, 2012-12)
Adult hamsters exposed to short photoperiods show a marked atrophy of their internal reproductive organs, including a reduction in size, though not number of Leydig cells. Transforming growth factor-β1 (TGF-β1) is involved ...
Insulin-degrading enzyme: Structure-function relationship and its possible roles in health and disease
(Bentham Science Publishers, 2009-11)
Insulin-degrading enzyme (IDE) or insulysin is a highly conserved Zn 2+-dependent endopeptidase with an "inverted" HxxEH motif. In vivo, IDE contributes to regulate the steady state levels of peripheral insulin and cerebral ...
Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-κ B ligand, interleukin (IL) -17, IL-10 and transforming growth factor-β during the progression of chronic periodontitis
(2009)
Aim: T regulatory (Treg) cells have been detected in periodontitis lesions, and forkhead box P3 (Foxp3) expression has been negatively correlated to receptor activator of nuclear factor-κ B ligand (RANKL). The aim of this ...