Buscar
Mostrando ítems 861-870 de 1734
Inhibition of Junín virus replication by small interfering RNAs
(Elsevier Science, 2009-10)
Junín virus (JUNV), the etiological agent of the Argentine hemorrhagic fever, has a single-stranded RNA genome with ambisense expression which encodes for five proteins. In previous works we have demonstrated that the Z ...
Targeting Tumor-Associated Macrophages and Inhibition of MCP-1 Reduce Angiogenesis and Tumor Growth in a Human Melanoma Xenograft
(Elsevier, 2007)
Chemokines such as monocyte chemoattractant protein (MCP)-1 are key agonists that attract macrophages to tumors. In melanoma, it has been previously shown that variable levels of MCP-1/CCL2 appear to correlate with ...
Cyclin T1 overexpression induces malignant transformation and tumor growth
(Landes Bioscience, 2010)
Human PTEFb is a protein kinase composed by CDK9 and Cyclin T that controls the elongation phase of RNA Pol II. This complex also affects the activation and differentiation program of lymphoid cells. In this study we found ...
MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells
(Academic Press Inc Elsevier Science, 2010-06)
Leptin, the LEP gene product, is produced in placenta where it has been found to be an important autocrine signal for trophoblastic growth during pregnancy. Thus, we have recently described the antiapoptotic and trophic ...
Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors
(Springer, 2018-02)
Pituitary tumors are the most common primary intracranial neoplasms. Humanin (HN) and Rattin (HNr), a rat homolog of HN, are short peptides with a cytoprotective action. In the present study, we aimed to evaluate whether ...
Reduction of G protein-coupled receptor kinase 2 expression in U-937 cells attenuates H2 histamine receptor desensitization and induces cell maturation
(American Society for Pharmacology and Experimental Therapeutics, 2002-12)
Histamine and H2 agonists transiently induce an important cAMP response in promonocytic U-937 cells but fail to induce monocytic differentiation because of a rapid receptor desensitization mediated by G protein-coupled ...
Downregulation of fibronectin transcription in highly metastatic adenocarcinoma cells
(Wiley, 1998-12-22)
Silencing of fibronectin (FN) expression seems to be one of the key mechanisms underlying metastatic behaviour. An inverse correlation exists between FN expression levels and the metastatic potential of two related murine ...
Avaliação da inibição da atividade da fosfolipase citoplasmática A2 (cPLA2) sobre o ciclo de multiplicação do Vaccinia virus
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MICROBIOLOGIAPrograma de Pós-Graduação em MicrobiologiaUFMG, 2017-03-31)
Vaccinia virus (VACV), the prototype virus of the Poxviridae family, is an enveloped virus that carries out its multiplicative cycle entirely in the cytoplasm of the host cell. Throughout its multiplication cycle, VACV ...
Mecanismos moleculares das -toxinas da aranha Phoneutria nigriventer: papel na sinalização de cálcio em vias nociceptivas
(Universidade Federal de Minas GeraisUFMG, 2011-02-02)
Propagation of ascending painful signals involves ionic exchanges throughout the plasma membrane of nerve cells in response to an action potential. Calcium ions penetrate the cell, mainly through voltage gated calcium ...
Caracterização funcional do gene Hus1 de Trypanosoma cruzi
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2015-02-20)
The DNA damage response (DDR) is a coordinated mechanism of damage signaling, in which lesion detection leads to cell cycle arrest and recruitment of repair machinery. One branch of the DDR is activated by the ATR kinase. ...