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Mostrando ítems 11-20 de 20038
Non-coding transcript in T cells (NTT): Antisense transcript activates PKR and NF-kappa B in human lymphocytes
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008)
T cell activation is a complex process involving many steps and the role played by the non-protein-coding RNAs (ncRNAs) in this phenomenon is still unclear. The non-coding T cells transcript (NTT) is differentially expressed ...
The catalytic subunit of schizosaccharomyces pombe CK2 (Cka1) negatively regulates RNA polymerase II transcription through phosphorylation of positive cofactor 4 (PC4)
(MDPI, 2022)
Positive cofactor 4 (PC4) is a transcriptional coactivator that plays important roles in
transcription and DNA replication. In mammals, PC4 is phosphorylated by CK2, and this event
downregulates its RNA polymerase II ...
Reverse Transcription Errors and RNA-DNA Differences at Short Tandem Repeats
(2016-07-12)
Transcript variation has important implications for organismal function in health and disease. Most transcriptome studies focus on assessing variation in gene expression levels and isoform representation. Variation at the ...
Reverse Transcription Errors and RNA-DNA Differences at Short Tandem Repeats
(2016-07-12)
Transcript variation has important implications for organismal function in health and disease. Most transcriptome studies focus on assessing variation in gene expression levels and isoform representation. Variation at the ...
Immunomodulatory effect of vitamin D on the STATs and transcription factors of CD4+ T cell subsets in pregnant women with preeclampsia
(2022-01-01)
This study evaluated the in vitro modulatory effect of vitamin D (VD) on T cells, by determining the expression of STATs and the transcription factors of each CD4+ T cell subsets. Twenty women with preeclampsia (PE) and ...
Transcription initiation mapping in 31 bovine tissues reveals complex promoter activity, pervasive transcription, and tissue-specific promoter usage
(Cold Spring Harbor Laboratory Press, 2021-04)
Characterizing transcription start sites is essential for understanding the regulatory mechanisms that control gene expression. Recently, a new bovine genome assembly (ARS-UCD1.2) with high continuity, accuracy, and ...
Becoming a Selfish Clan: Recombination Associated to Reverse-Transcription in LTR Retrotransposons
(Oxford University Press, 2019-11)
Transposable elements (TEs) are parasitic DNA bits capable of mobilization and mutagenesis, typically suppressed by host's epigenetic silencing. Since the selfish DNA concept, it is appreciated that genomes are also molded ...
Screening of transcription factors involved in fetal hemoglobin regulation using phylogenetic footprinting
(2015-10-27)
Fetal hemoglobin (Hb F) is an important genetic modulator of the beta-hemoglobinopathies. The regulation of Hb F levels is influenced by transcription factors. We used phylogenetic footprinting to screen transcription ...
Multiple mechanisms of growth hormone-regulated gene transcription
(Elsevier, 2007)
Diverse physiological actions of growth hormone (GH) are mediated by changes in gene transcription. Transcription can be regulated at several levels, including post-translational modification of transcription factors, and ...