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Immunization with antigen-pulsed dendritic cells significantly improves the immune response to weak self-antigens
(ELSEVIER GMBH, 2005-09-02)
Dendritic cells (DCs) are the only professional antigen-presenting cells endowed with the ability to stimulate naı¨ve T
cells and initiate a primary immune response. For this reason, DC-based immunization has been shown ...
The CREB-binding protein (CBP) cooperates with the serum response factor for transactivation of the c-fos serum response element
The serum response element is one of the major promoter elements of the immediate early response to extracellular signals. The serum response element includes two main binding sites for proteins: the Ets box, which binds ...
Transactivation activity and nucleocytoplasmic transport of beta-catenin are independently regulated by its C-terminal end
(2015)
The key protein in the canonical Wnt pathway is beta-catenin, which is phosphorylated both in absence and presence of Wnt signals by different kinases. Upon activation in the cytoplasm, beta-catenin can enter into the ...
Uncoupling the Folding and Binding of an Intrinsically Disordered Protein
(Academic Press Ltd - Elsevier Science Ltd, 2018-08)
The relationship between helical stability and binding affinity was examined for the intrinsically disordered transactivation domain of the myeloblastosis oncoprotein, c-Myb, and its ordered binding partner, KIX. A series ...