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Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) Activation Balance Astrocyte Polarization into a Proinflammatory Phenotype
(Springer, 2017-05)
Astrocytes react to brain injury with a generic response known as reactive gliosis, which involves activation of multiple intracellular pathways including several that may be beneficial for neuronal survival. However, by ...
Papel dos receptores do tipo Toll endossomais na resistência à infecção por Toxoplasma gondii
(Universidade Federal de Minas GeraisUFMG, 2013-03-01)
Toxoplasma gondii is an obligate intracellular parasite belonging to the phylum apicomplexa and can virtually infect all warm-blood vertebrates. Although humans are considered accidental intermediate hosts, one third of ...
Aspectos reprodutivos e produtivos de vacas da raça holandesa e expressão gênica endometrial de receptores tipo "toll" e -defensina 5 após o parto
(Universidade Federal de Minas GeraisUFMG, 2010-02-09)
Holstein females, from first to third lactation (n = 103), were submitted to endometrial biopsies between six and 12 hours postpartum, in order to compare the gene expression of toll-like receptors (TLRs) 1/6, 2, 4 and 5, ...
Caracterização funcional da região promotora do gene Rasgef1b e avaliação de componentes da via de sinalização de receptores do tipo toll (TLRs)
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Biologia CelularUFMG, 2016-02-19)
The guanine nucleotide exchange factor RasGEF1b is encoded by a gene whose expression is induced in innate immune cells in response to the activation of Toll-like receptors (TLRs). RasGEF1b mRNA levels are increased in ...
Expression of non-TLR pattern recognition receptors in the spleen of BALB/c mice infected with Plasmodium yoelii and Plasmodium chabaudi chabaudi AS
(FUNDACO OSWALDO CRUZRIO DE JANEIRO, RJ, 2012)
The spleen plays a crucial role in the development of immunity to malaria, but the role of pattern recognition receptors (PRRs) in splenic effector cells during malaria infection is poorly understood. In the present study, ...
Efeito da própolis in vivo sobre a expressão de receptores semelhantes a Toll (TLR-4 e TLR-2) e produção de citocinas por camundongos BALB/c
(Universidade Estadual Paulista (Unesp), 2009-08-07)
A própolis tem sido motivo de intensa investigação científica e sua ação imunomoduladora vem sendo mencionada. A recente descoberta e caracterização da família dos receptores semelhantes a Toll (TLR) tem desencadeado grande ...