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MKK3/6-p38 MAPK signaling is required for IL-1 beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells
(Mary Ann Liebert, Inc., 2006-10-01)
Coupled bone turnover is directed by the expression of receptor-activated NF-kappa B ligand (RANKL) and its decoy receptor, osteoprotegerin (OPG). Proinflammatory cytokines, such as interleukin-1 beta (IL-1 beta) and tumor ...
Tadalafil analgesia in experimental arthritis involves suppression of intra-articular TNF release
(WILEY-BLACKWELL, 2011)
BACKGROUND AND PURPOSE We investigated the effect of the phosphodiesterase-5 inhibitor, tadalafil, on the acute hypernociception in rat models of arthritis. EXPERIMENTAL APPROACH Rats were treated with either an intra-articular ...
Autophagy mediates tumor necrosis factor-alpha-induced phenotype switching in vascular smooth muscle A7r5 cell line
(Public library science, 2018)
Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis ...
Vascular Damage In Resistant Hypertension: Tnf-alpha Inhibition Effects On Endothelial Cells
(HINDAWI PUBLISHING CORPNEW YORK, 2015)
Effects of Protein-Energy Malnutrition on NF-KappaB Signalling in Murine Peritoneal Macrophages
(SPRINGER/PLENUM PUBLISHERS, 2010)
Protein-energy malnutrition (PEM) is an important public health problem affecting millions of people worldwide. PEM decreases resistance to infection, impairing a number of physiological processes. In unstimulated cells, ...
Role of cytokines (TNF-alpha, IL-1 beta and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide
(SPRINGER, 2008)
Introduction Irinotecan (CPT-11) is an inhibitor of DNA topoisomerase I and is clinically effective against several cancers. A major toxic effect of CPT-11 is delayed diarrhea; however, the exact mechanism by which the ...
Tumor necrosis factor-alpha activates nuclear factor-kappa B but does not regulate progesterone production in cultured human granulosa luteal cells
(PARTHENON PUBLISHING GROUP, 2007-07)
Background. The role of tumor necrosis factor-alpha (TNF-alpha) in granulosa luteal cell function and steroidogenesis is still controversial. Our aim was to examine the steroiclogenic response, together with the simultaneous ...
Role of protein kinase A signaling pathway in cyclosporine nephrotoxicity
(Informa Healthcare, 2014-09-01)
Cyclosporine is an important immunosuppressive agent; however, nephrotoxicity is one of the main adverse effects. The purpose of this study was to evaluate the effect of inhibiting the protein kinase A (PKA) signaling ...