Now showing items 11-20 of 785
Chronic expression of transforming growth factor-beta enhances adult neurogenesis
Neural stem cells reside in two neurogenic regions of the adult brain: the dentate gyrus of the hippocampus (DG) and the subventricular zone (SVZ). Their proliferation, differentiation, migration and survival are modulated ...
In vivo effects of TGF beta 1 on the the growth of gastric epithelium in suckling rats
(ELSEVIER SCIENCE BV, 2008)
As the content of Transforming Growth Factor-beta (TGF beta) wanes in the milk of lactating rat, an increase in TGF beta is observed in the gastric epithelia concomitant with differentiation of the glands upon weaning. ...
TGF-beta autocrine pathway and MAPK signaling promote cell invasiveness and in vivo mammary adenocarcinoma tumor progression
(Spandidos Publ Ltd, 2012-08)
Breast cancer progression and metastasis have been linked to abnormal signaling by transforming growth factor-beta (TGF-beta) cytokines. In early-stage breast cancers, TGF-beta exhibits tumor suppressor activity by repressing ...
JNK mediates TGF-beta 1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes
In this study we analyzed the role of the c-Jun N-terminal kinases (JNK) pathway in the TGF-beta 1 stimulation of urokinase-type plasminogen activator (uPA), initial stages of epithelial-mesenchymal transdifferentiation ...
Thyroid Hormone Increases TGF-beta 1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors
(HINDAWI PUBLISHING CORPORATION, 2010)
TH-induced cardiac hypertrophy in vivo is accompanied by increased cardiac Transforming Growth Factor-beta 1 (TGF-beta 1) levels, which is mediated by Angiotensin II type 1 receptors (AT1R) and type 2 receptors (AT2R). ...
Sex differences in the pituitary transforming growth factor-beta1 (TGF-beta1) system: studies in a model of resistant prolactinomas
(Endocrine Soc, 2013-09-05)
Dopamine and estradiol interact in the regulation of lactotroph cell proliferation and prolactin secretion. Ablation of the dopamine D2 receptor gene (Drd2 / ) in mice leads to a sexually dimorphic phenotype of hyperprolactinemia ...
MicroRNA miR-146b-5p regulates signal transduction of TGF-beta by repressing SMAD4 in thyroid cancer
(NATURE PUBLISHING GROUPLONDON, 2012)
MicroRNAs (miRNA) are small non-coding RNAs involved in post-transcriptional gene regulation that have crucial roles in several types of tumors, including papillary thyroid carcinoma (PTC). miR-146b-5p is overexpressed in ...
Developing human minor salivary glands: morphological parallel relation between the expression of TGF-beta isoforms and cytoskeletal markers of glandular maturation
Morphogenesis of salivary glands involves complex coordinated events. Synchronisation between cell proliferation, polarisation and differentiation, which are dependent on epithelial-mesenchymal interactions and on the ...
Effect of metformin on markers of epithelial mesenchymal transition induced by TGF-beta in mammary cells
(Spandidos Publ Ltd, 2014)