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Melatonin reduces cortisol response to ACTH in humans La melatonina reduce la respuesta de cortisol al ACTH en humanos
(2008)
Background: Melatonin receptors are widely distributed in human tissues but they have not been reported in human adrenal gland. Aim: To assess if the human adrenal gland expresses melatonin receptors and if melatonin affects ...
Trypanosoma cruzi evades the complement system as an efficient strategy to survive in the Mammalian host: the specific roles of host/parasite molecules and Trypanosoma cruzi Calreticulin
(Frontiers media SA, 2017)
American Trypanosomiasis is an important neglected reemerging tropical parasitism,
infecting about 8 million people worldwide. Its agent, Trypanosoma cruzi, exhibits
multiple mechanisms to evade the host immune response ...
Ca2+ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells
(American Physiological Society, 2014)
Elevating cytosolic Ca2+ stimulates glucose uptake in skeletal muscle, but how Ca2+ affects intracellular traffic of GLUT4 is unknown. In tissue, changes in Ca2++ leading to contraction preclude analysis of the impact of ...
Self-assembling functional programmable protein array for studying protein-protein interactions in malaria parasites
(2018)
Background: Plasmodium vivax is the most widespread malarial species, causing significant morbidity worldwide. Knowledge is limited regarding the molecular mechanism of invasion due to the lack of a continuous in vitro ...
Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species
(Endocrine Society, 2015)
Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated ...
Senescent CD4+CD28− T lymphocytes as a potential driver of Th17/Treg imbalance and alveolar bone resorption during periodontitis
(MDPI, 2022)
Senescent cells express a senescence-associated secretory phenotype (SASP) with a pro-inflammatory bias, which contributes to the chronicity of inflammation. During chronic inflammatory diseases, infiltrating CD4(+) T ...
Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients
(2012)
Toll-like receptor 4 (TLR4) is expressed on dendritic cells (DCs), sensing environmental danger molecules that induce their activation and maturation. Recently, we reported a method for the production of therapeutic DCs ...
Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury
(Elsevier, 2015)
BACKGROUND Exosomes are nanometer-sized vesicles released from cells into the blood, where they can transmit
signals throughout the body. Shown to act on the heart, exosomes’ composition and the signaling pathways they ...
Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells
(MDPI, 2020)
Epithelial ovarian cancer (EOC) is a lethal gynaecological neoplasm characterized by rapid growth and angiogenesis. Nerve growth factor (NGF) and its high affinity receptor tropomyosin receptor kinase A (TRKA) contribute ...
Wave friction factor rediscovered
(Springer, 2012)
The wave friction factor is commonly expressed
as a function of the horizontal water particle semi-excursion
(Awb) at the top of the boundary layer. Awb, in turn, is
normally derived from linear wave theory by UwbTw
2p ...