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Regulation of PKD1-mediated Golgi to cell surface trafficking by Gαq subunits
(Wiley, 2013-12)
Background Information: Heterotrimeric GTP-binding proteins play a key role in cell trafficking regulation. Above all, specific Gβγ subunits have been shown to be a major component of a signal transduction pathway, which ...
Chemical modification of SH groups of E. coli Phosphofructokinase-2 induces subunit dissociation: Monomers are inactive but preserve ligand binding properties
(Taylor & Francis, 2000)
Modification of Escherichia coli phosphofructokinase-2 (Pfk-2) with N- (1-pyrenil)maleimide results in an enzyme form that is inactive. However, the rate of modification is drastically reduced in the presence of the ...
The association of Na,K-ATPase subunits studied by circular dichroism, surface tension and dilatational elasticity
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008)
Different stoichiometries are observed between alpha and beta subunits of Na,K-ATPase that depend on the method employed to solubilize and purify the enzyme. It is not known whether this variability is due to loss of ...
Pituitary glycoprotein hormone a-subunit secretion by cirrhotic patients
(Associação Brasileira de Divulgação Científica, 1999-01-01)
Secretion of the a-subunit of pituitary glycoprotein hormones usually follows the secretion of intact gonadotropins and is increased in gonadal failure and decreased in isolated gonadotropin deficiency. The aim of the ...
Echinococcus granulosus Antigen B Structure: Subunit Composition and Oligomeric States
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
Background: Antigen B (AgB) is the major protein secreted by the Echinococcus granulosus metacestode and is involved in key host-parasite interactions during infection. The full comprehension of AgB functions depends on ...
Determination of the Stoichiometry between α- and γ1 Subunits of the BK Channel Using LRET
(Biophysical Society, 2018)
© 2018 Biophysical Society Two families of accessory proteins, β and γ modulate BK channel gating and pharmacology. Notably, in the absence of internal Ca2+, the γ1 subunit promotes a large shift of the BK conductance-voltage ...
Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
(BioMed Central, 2019-06)
Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study, we explored ...
β1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel
(National Academy of Sciences, 2016)
Large-conductance Ca2+- and voltage-activated K+ (BK) channels are involved in a large variety of physiological processes. Regulatory β-subunits are one of the mechanisms responsible for creating BK channel diversity ...
beta 1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel
(Natl Acad Sciences, 2016)
Large-conductance Ca2+- and voltage-activated K+ (BK) channels are involved in a large variety of physiological processes. Regulatory beta-subunits are one of the mechanisms responsible for creating BK channel diversity ...